SAB4700182
Monoclonal Anti-CD44-FITC antibody produced in mouse
clone MEM-85, purified immunoglobulin, buffered aqueous solution
Synonim(y):
Anti-Pgp-1
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About This Item
Kod UNSPSC:
12352203
NACRES:
NA.44
Polecane produkty
pochodzenie biologiczne
mouse
białko sprzężone
FITC conjugate
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
MEM-85, monoclonal
Postać
buffered aqueous solution
reaktywność gatunkowa
human
metody
flow cytometry: suitable
izotyp
IgG2b
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
2-8°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... CD44(960)
Powiązane kategorie
Opis ogólny
The CD44 (cell-surface glycoprotein) gene with 20 exons is mapped to human chromosome 11p13. The gene codes for a transmembrane glycoprotein.
The antibody MEM-85 reacts with both cell surface-expressed and soluble form of CD44 antigen (Phagocyte glycoprotein 1), a 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes.
Immunogen
Leukocytes of a patient suffering from LGL Type Leukaemia.
Zastosowanie
Monoclonal Anti-CD44-FITC antibody produced in mouse has been used as a reagent to distinguish HeLa (cancer) cells from chondrocyte (normal) cells.
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Działania biochem./fizjol.
CD44 (cell-surface glycoprotein) is involved in cell-cell and cell-extracellular matrix interactions. It plays an important role in lymphocyte homing and lymphocyte activation. It also acts as a metastasis suppressor gene for prostatic cancer. Overexpression of CD44 leads to esophageal squamous cell carcinoma (ESCC). CD44 inhibits macrophage multinucleation by interacting with its ligands, hyaluronic acid, chondroitin sulfates and osteopontin. 100kDa form of CD44, facilitates the binding of poliovirus to HeLa cells. In addition, it also implicated in the infection of mononuclear phagocytes by human immunodeficiency virus (HIV).
Cechy i korzyści
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Postać fizyczna
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Fabrication and modification of dual-faced nano-mushrooms for tri-functional
cell theranostics: SERS/fluorescence signaling, protein targeting, and drug
delivery?
Hsieh H Y
Journal of Materials Chemistry, 22, 20918?20928-20918?20928 (2012)
BGMUT: NCBI dbRBC database of allelic variations of genes encoding antigens of blood group systems.
Patnaik SK
Nucleic Acids Research, 40, D1023-D1023 (2012)
Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance
Whelan KA
Oncogene, 36, 4843-4858 (2017)
CD44 occupancy prevents macrophage multinucleation.
Sterling H
The Journal of Cell Biology, 143, 837-847 (1998)
Guang-Yuh Chiou et al.
Scientific reports, 7(1), 2172-2172 (2017-05-21)
Colorectal cancers (CRCs) are a critical health issue worldwide. Cancer stem cell (CSC) lineages are associated with tumour transformation, progression, and malignant transformation. However, how lineages are transformed and how chemoresistance is acquired by CRCs remain largely unknown. In this
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