Sigma-Aldrich does not test saquinavir mesylate, product S8451, for solution stability. However, it is noted that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month. Whenever possible, solutions should be made up and used on the same day.
S8451
Saquinavir mesylate
≥98% (HPLC), HIV Protease Inhibitor, powder
Synonim(y):
(2S)-N1[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-Dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate, Ro-31-8959
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Wybierz wielkość
10 MG
417,00 zł
50 MG
1710,00 zł
417,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C38H50N6O5·CH4O3S
Numer CAS:
Masa cząsteczkowa:
766.95
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Pozwól nam pomócNazwa produktu
Saquinavir mesylate, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥5 mg/mL
originator
Roche
storage temp.
2-8°C
SMILES string
CS(O)(=O)=O.CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(N)=O)NC(=O)c4ccc5ccccc5n4
InChI
1S/C38H50N6O5.CH4O3S/c1-38(2,3)43-37(49)32-20-26-14-7-8-15-27(26)22-44(32)23-33(45)30(19-24-11-5-4-6-12-24)41-36(48)31(21-34(39)46)42-35(47)29-18-17-25-13-9-10-16-28(25)40-29;1-5(2,3)4/h4-6,9-13,16-18,26-27,30-33,45H,7-8,14-15,19-23H2,1-3H3,(H2,39,46)(H,41,48)(H,42,47)(H,43,49);1H3,(H,2,3,4)/t26-,27+,30-,31-,32-,33+;/m0./s1
InChI key
IRHXGOXEBNJUSN-YOXDLBRISA-N
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Powiązane kategorie
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Ta pozycja | |||
|---|---|---|---|
| form powder | form - | form - | form - |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 15-25°C | storage temp. 2-8°C |
| solubility DMSO: ≥5 mg/mL | solubility - | solubility - | solubility - |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
General description
Saquinavir is a peptidomimetic hydroxyethylamine inhibitor, which is used to treat human immunodeficiency virus (HIV) infection.
Application
Saquinavir mesylate may be used in cell signaling and immunology studies.
Biochem/physiol Actions
Saquinavir is an HIV Protease Inhibitor used in antiretroviral therapy.
Saquinavir is an HIV Protease Inhibitor used in antiretroviral therapy. It inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at saquinavir as a possible anti-cancer agent.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Marija Mojic et al.
Molecular pharmacology, 82(4), 700-710 (2012-07-17)
We have examined the influence of the nitric oxide (NO)-modified anti-inflammatory drug (S,R)-3-phenyl-4,5-dihydro-5-isoxasole acetic acid (VGX-1027) named GIT-27NO or the NO-modified antiviral drug saquinavir (Saq) named Saq-NO on two colon cancer cell lines, mouse CT26CL25 and human HCT116. The effects
Atsuko Tomaru et al.
Drug metabolism and pharmacokinetics, 30(3), 221-226 (2015-04-18)
Modulation of CYP3A and/or P-gp function by several excipients has been reported. However, relatively few studies have investigated their effects in humans. Therefore, the aim of this clinical study was to clarify the effects of Cremophor EL on the inhibition
Yung-Chih Kuo et al.
Colloids and surfaces. B, Biointerfaces, 101, 101-105 (2012-07-17)
Application of cationic solid lipid nanoparticles (CSLNs), comprising complex internal matrix and lipid-regulated external surface, is an intriguing issue in current bionanotechnology. This study presents dissolution kinetics of saquinavir (SQV) from CSLNs with cholesterol-mediated esterquat 1 (EQ 1) and biocompatibility
Zhenmin Liang
Bioanalysis, 4(10), 1227-1234 (2012-06-02)
Ionization matrix effects are one of the most difficult issues in LC-MS bioanalysis that are without a good and universal solution. Most people in the field are aware of it, but some are not sure how to deal with it.
Shigeyoshi Harada et al.
The Journal of general virology, 94(Pt 5), 933-943 (2013-01-05)
The initiation of drug therapy results in a reduction in the human immunodeficiency virus type 1 (HIV-1) population, which represents a potential genetic bottleneck. The effect of this drug-induced genetic bottleneck on the population dynamics of the envelope (Env) regions
Produkty
Discover Bioactive Small Molecules for ADME/Tox
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| S8451-10MG | 04061836960810 |
| S8451-50MG | 04061832632780 |
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What is the solution stability of Saquinavir mesylate, product S8451?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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