S7395

Spiperone

solid

• Synonim(y): 8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, R 5147, Spiroperidol
• Wzór empiryczny (zapis Hilla): C₂₃H₂₆FN₃O₂
• Numer CAS: 749-02-0
• Masa cząsteczkowa: 395.47
• NACRES: NA.77
• PubChem Substance ID: 24277908
• UNSPSC Code: 12352200
• EC Number: 212-024-0
• MDL number: MFCD00055099
• Form: solid

Właściwości

• form: solid
• Quality Segment: 200
• color: light yellow
• solubility: H₂O: slightly soluble 0.2 mg/mL, 0.1 M HCl: slightly soluble 0.3 mg/mL, ethanol: 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL
• SMILES string: Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4
• InChI: 1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
• InChI key: DKGZKTPJOSAWFA-UHFFFAOYSA-N
• Gene Information: human ... ADRA1B(147), DRD2(1813), DRD3(1814), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356) ; rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413), Adra2a(25083), Drd1a(24316), Drd2(24318), Drd3(29238), Htr1a(24473), Htr2a(29595), Htr2c(25187), Htr7(65032)

Opis

General description

Spiperone is a butyrophenone antipsychotic agent. It induces calcium-dependent chloride secretion in the airway and functions as a potential therapeutic target for cystic fibrosis.

Application

Spiperone has been used to block the actions of 5-hydroxytryptamine (5-HT) receptor. It also has been used to study its anti tumor effects in glioblastoma (GBM) cell lines.

Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.⁶

Biochem/physiol Actions

Selective D₂ dopamine receptor antagonist; α_1B-adrenoceptor antagonist; mixed 5-HT_2A/5-HT₁ serotonin receptor antagonist; antipsychotic.

Preparation Note

Solutions may be stored for 1-2 days at 4 °C.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H361
• pcodes: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges