Retinol Binding Protein is a transport protein of Vitamin A. There are a number of publications available regarding the biological activtity and functionality of this protein. See the link below to access a review article that may be of interest:
https://www.frontiersin.org/articles/10.3389/fphys.2021.659977/full
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R9388
Retinol Binding Protein from human urine
buffered aqueous solution
Synonim(y):
CRBP, Cellular retinol binding protein, RBP, RBP-1, Retinol Binding Protein I
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
0.5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1270,00 zł |
Informacje o tej pozycji
Form:
buffered aqueous solution
Assay:
≥85% (SDS-GE)
Biological source:
human urine
1270,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócbiological source
human urine
Quality Segment
assay
≥85% (SDS-GE)
form
buffered aqueous solution
technique(s)
cell culture | embryo: suitable, transfection: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... RBP1(5947)
General description
Retinol Binding Protein (RBP) is a member of lipocalin superfamily. The normal concentration of RBP in serum is 40 to 50 μg/mL and has a molecular weight of 21 kDa. It has a turnover rate of 4 to 24 h. RBP is produced in the liver in response to retinol binding trigger. It is also produced in kidney, sertoli cells of testis. RBP contains a single globular domain and a highly conserved N-terminal region. It has eight antiparallel β sheets in the centre which binds retinol. In human chromosome, the gene encoding RBP is localised at 3q23.
Application
Retinol Binding Protein from human urine has been used:
- as one of the protein in microinjecting mesencephalic cavity of chicken eggs to monitor embryonic cerebrospinal fluid/embryonic serum protein transfer
- as an additive in basal medium for RNA transfection experiments
- in the antibody-derivatized affinity pipettes preparation for the capture of affinity proteins
Biochem/physiol Actions
Inflammation induced by lipopolysaccharide (LPS) exposure caused a reduction in the level of retinol binding protein produced by the liver.
Retinol Binding Protein (RBP) is a specific protein for the transport of vitamin A. The apo-RBP, formed after delivering retinol to the tissues is catabolized by the kidney. The plasma concentration of RBP is less in diabetes mellitus patients. RBP binds to the carrier protein transerythrin, to prevent its loss during glomerular filtration. RBP is implicated in initial neurogenesis and neuroepithelial cell proliferation. RBP is responsible for blepharophimosis syndrome (BPES).
Physical form
Solution in 10 mM sodium phosphate, pH 7.4, 150 mM NaCl, and 0.05% NaN3
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Ta pozycja | |||
|---|---|---|---|
| description buffered aqueous solution | description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | description clone 4F3, purified immunoglobulin, buffered aqueous solution |
| assay ≥85% (SDS-GE) | assay ≥98% (HPLC), ≥98% (SDS-PAGE) | assay ≥98% (HPLC), ≥98% (SDS-PAGE) | assay - |
| technique(s) transfection: suitable, cell culture | embryo: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) western blot: 1-5 μg/mL, indirect ELISA: suitable |
| biological source human urine | biological source human | biological source human | biological source mouse |
| form buffered aqueous solution | form lyophilized | form lyophilized | form buffered aqueous solution |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information human ... RBP1(5947) | Gene Information human ... IGFBP1(3484) | Gene Information human ... IGFBP3(3486) | Gene Information human ... RBP3(5949) |
Klasa składowania
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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