R4408

Chloramphenicol

Ready Made Solution, 100 mg/mL in ethanol: isopropanol (95:5), ≥98% (HPLC)

• Synonim(y): D-(-)-threo-2,2-Dichloro-N-[β-hydroxy-α−(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide
• Kod UNSPSC: 51102831
• NACRES: NA.85

Właściwości

• Poziom jakości: 200
• Próba: ≥98% (HPLC)
• Postać: solution
• stężenie: 100 mg/mL in ethanol: isopropanol (95:5)
• spektrum działania antybiotyku: Gram-negative bacteria; Gram-positive bacteria
• Tryb działania: protein synthesis | interferes
• Warunki transportu: dry ice
• temp. przechowywania: −20°C

Opis

Zastosowanie

Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.

Działania biochem./fizjol.

Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.

Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.

Opakowanie

10ml

Uwaga dotycząca przygotowania

This product is a ready made solution of 100 mg/mL in ethanol:isopropanol (95:5). It is shipped in dry ice and stored at -20°C.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Storage class (TRGS 510): Flammable liquids")

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS08,GHS05
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H225,H318,H351,H361fd
• Zwroty wskazujące środki ostrożności: P202 - P210 - P233 - P280 - P305 + P351 + P338 - P308 + P313
• Klasyfikacja zagrożeń: Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2
• Kod klasy składowania: 3 - Flammable liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): 57.2 °F - closed cup
• Temperatura zapłonu (°C): 14.0 °C - closed cup