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Merck

P2254

Poly-L-proline

suitable for ligand binding assays, Mol wt 1,000-10,000

Synonim(y):

L-Proline homopolymer

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Wybierz wielkość

100 MG

2390,00 zł

500 MG

8390,00 zł

2390,00 zł


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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C5H9NO2
Numer CAS:
Masa cząsteczkowa:
115.13
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:

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Nazwa produktu

Poly-L-proline, mol wt 1,000-10,000

SMILES string

OC(=O)C1CCCN1

InChI

1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)

InChI key

ONIBWKKTOPOVIA-UHFFFAOYSA-N

form

powder

mol wt

1,000-10,000

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

Quality Level

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Ta pozycja
G3002A3253P2533
form

powder

form

solid

form

powder

form

powder or solid

technique(s)

ligand binding assay: suitable

technique(s)

ligand binding assay: suitable

technique(s)

ligand binding assay: suitable

technique(s)

ligand binding assay: suitable

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white

color

white

color

white to off-white

color

white to off-white

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

mol wt

1,000-10,000

mol wt

-

mol wt

-

mol wt

15,000-30,000

Application


  • Highly sensitive and selective electrochemical sensor for simultaneous determination of gallic acid, theophylline and caffeine using poly(l-proline) decorated carbon nanotubes in biological and food samples.: This study presents an innovative electrochemical sensor that utilizes poly-L-proline decorated carbon nanotubes for the simultaneous detection of gallic acid, theophylline, and caffeine. This sensor demonstrates high sensitivity and selectivity, making it suitable for applications in both biological and food samples (Aschemacher NA et al., 2024).

  • Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline N-carboxyanhydride.: This research explores the water-assisted and protein-initiated ring-opening polymerization of proline N-carboxyanhydride, leading to the rapid and controlled synthesis of poly-L-proline. The study highlights the method′s efficiency and potential for producing high-quality poly-L-proline for various applications (Hu Y et al., 2022).

  • Phosphorylation of the actin-binding protein profilin2a at S137 modulates bidirectional structural plasticity at dendritic spines.: This study examines the role of poly-L-proline regions in the actin-binding protein profilin2a, specifically focusing on its phosphorylation at S137. The findings reveal how these modifications impact the structural plasticity of dendritic spines, providing insights into neuronal function and plasticity (Cornelius J et al., 2023).

  • A structural model of the profilin-formin pacemaker system for actin filament elongation.: This paper presents a structural model involving poly-L-proline regions within the profilin-formin complex, which acts as a pacemaker for actin filament elongation. The study offers a detailed understanding of the molecular mechanisms driving actin dynamics and cellular movement (Schutt CE et al., 2022).

Biochem/physiol Actions

Poly-L-Proline is an antigenic homopolymer.

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Bindu Ambaru et al.
Molecular and biochemical parasitology, 238, 111280-111280 (2020-05-15)
Profilins are the key regulators of actin dynamics in all eukaryotic cells. However, little information is available on their biochemical properties and functions in kinetoplastids, such as Trypanosoma and Leishmania. We show here that Leishmania parasites express only one homolog
Sebastien Lhomme et al.
The Journal of infectious diseases, 209(2), 300-303 (2013-08-22)
Hepatitis E virus (HEV) can chronically infect immunocompromised patients. The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies
Alexei A Adzhubei et al.
Journal of molecular biology, 425(12), 2100-2132 (2013-03-20)
The poly-l-proline type II (PPII) helix in recent years has emerged clearly as a structural class not only of fibrillar proteins (in collagen, PPII is a dominant conformation) but also of the folded and unfolded proteins. Although much less abundant
Conor C G Scully et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(49), 15612-15617 (2012-11-06)
Bent but not broken: cyclic oligoprolines are accessed in a reaction that effectively bends rigid oligoproline peptides (see scheme; TBDMS=tert-butyldimethylsilyl). The stitching is accomplished during macrocyclization enabled by aziridine aldehydes and isocyanides. Molecular modeling studies suggest that electrostatic attraction between
W Austin Elam et al.
Protein science : a publication of the Protein Society, 22(4), 405-417 (2013-01-24)
Intrinsically disordered (ID) proteins function in the absence of a unique stable structure and appear to challenge the classic structure-function paradigm. The extent to which ID proteins take advantage of subtle conformational biases to perform functions, and whether signals for

Produkty

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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