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M5269
Moniliformin sodium salt
from Fusarium proliferatum, tricarboxylic acid (TCA) cycle oxidation inhibitor
Synonim(y):
1-Hydroxycyclobut-1-ene-3,4-dione
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Informacje o tej pozycji
Wzór liniowy:
C4HO3Na
Numer CAS:
Masa cząsteczkowa:
120.04
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Quality level:
Informacje o cenach i dostępności nie są obecnie dostępne.
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Pozwól nam pomócNazwa produktu
Moniliformin sodium salt from Fusarium proliferatum,
Quality Level
storage temp.
2-8°C
SMILES string
O=C1C(C=C1[O-])=O.[Na+]
InChI
1S/C4H2O3.Na/c5-2-1-3(6)4(2)7;/h1,5H;/q;+1/p-1
InChI key
FERDNJVXTWPNSA-UHFFFAOYSA-M
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Ta pozycja | |||
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| Quality Level 200 | Quality Level 300 | Quality Level 100 | Quality Level 300 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
General description
Moniliformin (MON), a mycotoxin[1] and small ionic molecule[2], is present in various Fusarium species including Fusarium avenaceum, Fusarium subglutinans and Fusarium proliferatum.[1] It is present as sodium or potassium salt of semisquaric acid naturally.[1] MON is also present in maize and small-grain cereals.[2]
Application
Biochem/physiol Actions
Moniliformin (MON) is implicated for its toxic potential and may lead to respiratory distress and progressive muscular weakness in rats.[1] It inhibits the tricarboxylic acid (TCA) cycle oxidation step.[1] By acting as a pyruvate substrate, MON effectively inhibits thiamine pyrophosphate cofactor dependant enzymes and blocks the gluconeogenesis pathway.[1] ) Furthermore, MON also inhibits glutathione peroxidase and glutathione reductase leading to oxidative stress in myoblast.[2]
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Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Klasa składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
H R Burmeister et al.
Applied and environmental microbiology, 37(1), 11-13 (1979-01-01)
Fusarium moniliforme NRRL 6322 produced about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. The moniliformin was extracted from the grits with methanol, purified by preparative thin-layer chromatography, and crystallized from ether. The 50%
Silvio Uhlig et al.
International journal of food microbiology, 119(1-2), 17-24 (2007-09-22)
The Fusarium species complex found on small-grain cereals in Northern Europe is largely dominated by F. avenaceum, while other important species include F. tricinctum, F. poae, F. culmorum and F. graminearum. The dominance of F. avenaceum has in recent years
Fusarium species colonizing spears and forming mycotoxins in field samples of asparagus from Germany and Poland
Weber Z, et al.
Journal of Phytopathology, 209-216 null
Martina Jonsson et al.
Toxicology letters, 233(1), 38-44 (2014-12-09)
Moniliformin is a Fusarium mycotoxin mainly produced by several species infecting grains in different climatic conditions. According to our previous studies, it is acutely toxic to rats, with an LD50 cut-off value of 25mg/kg b.w. To further assess the possible
Katharina Walburga von Bargen et al.
Journal of agricultural and food chemistry, 60(14), 3586-3591 (2012-03-21)
Moniliformin is a mycotoxin produced by fungi of the Fusarium genus and occurs as a contaminant of different cereals worldwide. This study describes the first application of isotopically labeled (13)C(2)-moniliformin for the analysis of moniliformin in cereals. Moniliformin is a
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Product Information Sheet
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| M5269-1MG | 04061826676066 |
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