Kluczowe dokumenty

Wyświetl całą dokumentację

Przejdź do

M2824

Meptazinol hydrochloride

Name: Meptazinol hydrochloride
Brand: SIGMA

Synonim(y):

3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-phenol hydrochloride, IL-22811 hydrochloride, WY-22811 hydrochloride

Zaloguj się, aby wyświetlić ceny organizacyjne i kontraktowe.

Wybierz wielkość

Zmień widok

Gabaryty przesyłki	SKU	Dostępność	Cena netto

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₅H₂₃NO· HCl

Numer CAS:

59263-76-2

Masa cząsteczkowa:

269.81

NACRES:

NA.77

PubChem Substance ID:

329817952

UNSPSC Code:

12352200

EC Number:

261-683-0

MDL number:

MFCD00941476

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Informacje o cenach i dostępności nie są obecnie dostępne.

Pomoc techniczna

Potrzebujesz pomocy? Nasz zespół doświadczonych naukowców chętnie Ci pomoże.

Pozwól nam pomóc

assay

≥98% (HPLC)

Quality Level

100

form

powder

color

white to off-white

solubility

H₂O: >10 mg/mL

originator

Wyeth

SMILES string

Cl.CCC1(CCCCN(C)C1)c2cccc(O)c2

InChI

1S/C15H23NO.ClH/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13;/h6-8,11,17H,3-5,9-10,12H2,1-2H3;1H

InChI key

MPJUSISYVXABBH-UHFFFAOYSA-N

Szukasz podobnych produktów? Odwiedź Przewodnik dotyczący porównywania produktów

Powiązane kategorie

Bioactive Small Molecule Inhibitors

Porównaj podobne pozycje

Wyświetl pełne porównanie

Pokaż różnice

1 of 1

Ta pozycja	SML1555	SML1770	SML2716
Sigma-Aldrich M2824 Meptazinol hydrochloride	Sigma-Aldrich SML1555 MS023 hydrochloride	Sigma-Aldrich SML1770 PhiKan083 hydrochloride	Sigma-Aldrich SML2716 Pitolisant hydrochloride
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility H₂O: >10 mg/mL	solubility H₂O: 20 mg/mL, clear	solubility H₂O: 2 mg/mL, clear	solubility H₂O: 2 mg/mL, clear
originator Wyeth	originator -	originator -	originator -
color white to off-white	color white to light brown	color white to beige	color white to beige

Biochem/physiol Actions

Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic.

Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Ta strona może zawierać tekst przetłumaczony maszynowo.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Klasa składowania

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number

Nie widzisz odpowiedniej wersji?

Jeśli potrzebujesz konkretnej wersji, możesz wyszukać konkretny certyfikat według numeru partii lub serii.

Wyszukaj dokument COA

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol.

Qiong Xie et al.

Bioorganic & medicinal chemistry letters, 15(22), 4953-4956 (2005-09-13)

Based on the known coumarin-based prodrug system, a new meptazinol (Z)-3-[2-(propionyloxy) phenyl]-2-propenoic ester (3) was designed and synthesized as prodrug to minimize the first-pass effect of meptazinol (1) and improve the oral bioavailability. The prodrug (3) showed a 4-fold increase

Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property.

Wei Zheng et al.

Toxicology and applied pharmacology, 264(1), 65-72 (2012-07-31)

The strategy of dual binding site acetylcholinesterase (AChE) inhibition along with metal chelation may represent a promising direction for multi-targeted interventions in the pathophysiological processes of Alzheimer's disease (AD). In the present study, two derivatives (ZLA and ZLB) of a

Determination of the stereoselective aspects in in-vitro and in-vivo metabolism of the analgesic meptazinol by high-performance liquid chromatography.

C Rudolphi et al.

Journal of chromatography. B, Biomedical applications, 663(2), 315-326 (1995-01-20)

A reversed-phase high-performance liquid chromatographic method to separate meptazinol and its phase I metabolites has been developed using a LiChrosper 100 CN column and a mobile phase of trimethylammoniumacetate buffer (pH 5.5)-acetonitrile-methanol. Quantification of meptazinol and N-desmethylmeptazinol in biological samples

Liquid chromatography/positive ion electrospray tandem mass spectrometry method for the quantification of hydrochloride meptazinol in human plasma: application to a pharmacokinetic study.

Jian Qiao et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(30), 3787-3791 (2009-10-13)

A robust and validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method with positive electrospray ionization (ESI) was developed for the determination of hydrochloride meptazinol in human plasma. After liquid-liquid extraction of 200mul of human plasma, HPLC separation was achieved on a

Enhancement of systemic and CNS delivery of meptazinol hydrochloride by intranasal administration to rats.

Zhen-qi Shi et al.

Yao xue xue bao = Acta pharmaceutica Sinica, 40(8), 754-757 (2005-11-05)

To investigate the extent of systemic absorption and uptake of meptazinol (MEP) hydrochloride in cerebrospinal fluid (CSF) after intranasal administration on rats and compare with oral administration. CSF samples were collected by a serial sampling method. The concentration of MEP

Wyświetl wszystkie powiązane dokumenty

Produkty

Opioid Receptors

We offers many products related to opioid receptors for your research needs.

Numer pozycji handlu globalnego

SKU	NUMER GTIN
M2824-50MG	04061832557137
M2824-10MG	04061832557120

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej