M2420
Monoclonal Anti-Monocyte Chemotactic Protein-1 antibody produced in mouse
clone 24822, purified immunoglobulin, lyophilized powder
Synonim(y):
Anti-CCL2, Anti-MCP-1
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Wybierz wielkość
0.5 MG
4430,00 zł
4430,00 zł
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Informacje o tej pozycji
Conjugate:
unconjugated
Clone:
24822, monoclonal
Application:
Neutral, WB
Citations:
4
Przejdź do
Pomoc techniczna
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Pozwól nam pomócbiological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
24822, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
neutralization: suitable, western blot: suitable
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CCL2(6347)
1 of 4
Ta pozycja | |||
|---|---|---|---|
| clone 24822, monoclonal | clone polyclonal | clone 2E2, monoclonal | clone polyclonal |
| species reactivity human | species reactivity rat | species reactivity human | species reactivity human |
| Gene Information human ... CCL2(6347) | Gene Information human ... CCL2(6347) | Gene Information human ... CCL2(6347) | Gene Information human ... CCL2(6347) |
| biological source mouse | biological source rabbit | biological source mouse | biological source rabbit |
| conjugate unconjugated | conjugate - | conjugate unconjugated | conjugate unconjugated |
| antibody form purified immunoglobulin | antibody form affinity purified immunoglobulin | antibody form purified immunoglobulin | antibody form purified immunoglobulin |
General description
Monocyte Chemotactic Protein-1 (MCP-1) is a chemotactic factor that belongs to CC chemokine family and can attract basophils and monocytes but not eosinophils or neutrophils. It is produced in keratinocytes, fibroblasts, hepatoma cells and Type II pneumocytes in response to IL-1. It has a crucial role in recruiting immune cells to the site of antigens as well as behaves as an inflammatory mediator which stimulates the directional migration of T cells and monocytes. Monoclonal anti-Monocyte Chemotactic Protein-1 antibody is suitable for neutralization, in which it will not neutralize the activity of recombinant human MIP-1α, recombinant mouse MIP-1α or recombinant human RANTES. Mouse anti-Monocyte Chemotactic Protein-1 antibody reacts specifically with human MCP-1/CCL2.
Immunogen
recombinant human MCP-1/CCL2 expressed in E. coli.
Application
Monoclonal anti-Monocyte Chemotactic Protein-1 antibody can be used in western blotting.
Biochem/physiol Actions
The antibody will neutralize the biological activity of recombinant human MCP-1.This antibody does not exhibit cross-reactivity with recombinant human RANTES, recombinant human MIP-1α, or recombinant mouse MIP-1α..
Physical form
Lyophilized from a 0.2 μm solution in phosphate buffered saline containing carbohydrates.
Preparation Note
Purified using protein A.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
D D Taub et al.
The Journal of clinical investigation, 95(3), 1370-1376 (1995-03-01)
Monocyte chemotactic protein (MCP)-1, -2, and -3 all have been shown to induce monocyte/macrophage migration in vitro and MCP-1, also known as MCAF, chemoattracts basophils and mast cells. We report here that natural MCP-1 as well as synthetic preparations of
Haijun Zhang et al.
The journal of pain : official journal of the American Pain Society, 14(10), 1031-1044 (2013-06-04)
The use of paclitaxel (Taxol), a microtubule stabilizer, for cancer treatment is often limited by its associated peripheral neuropathy (chemotherapy-induced peripheral neuropathy [CIPN]), which predominantly results in sensory dysfunction, including chronic pain. Here we show that paclitaxel CIPN was associated
Y Furutani et al.
Biochemical and biophysical research communications, 159(1), 249-255 (1989-02-28)
cDNA clones having a nucleotide sequence encoding a human monocyte chemotactic and activating factor (MCAF) were isolated and sequenced. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of
Kenichiro Kobayashi et al.
Hepatology communications, 2(3), 230-236 (2018-03-07)
Liver fibrosis is a common complication associated with transient myeloproliferative disorder (TMD) in Down syndrome (DS). The exact molecular pathogenesis that regulates disease progression is largely unknown. We recently found serum and/or urinary monocyte chemoattractant protein-1 (MCP-1) as a novel
Powiązane treści
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| M2420-.5MG | 04061832714981 |
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