I9154
Interleukin-10 from rat
>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Synonim(y):
IL-10
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Wybierz wielkość
25 μG
2510,00 zł
5 μG
2227,00 zł
2510,00 zł
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Pozwól nam pomócbiological source
rat
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
1-35 ng/mL ED50
mol wt
predicted mol wt ~19 kDa
packaging
pkg of 5 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
rat ... Il10(25325)
1 of 4
Ta pozycja | |||
|---|---|---|---|
| assay >95% (SDS-PAGE) | assay ≥97% (SDS-PAGE and N-terminal analysis) | assay ≥97% (SDS-PAGE) | assay >97% (SDS-PAGE) |
| recombinant expressed in E. coli | recombinant expressed in baculovirus infected Sf21 cells | recombinant expressed in E. coli | recombinant expressed in baculovirus infected Sf21 cells |
| biological source rat | biological source human | biological source rat | biological source human |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
Application
Interleukin-10 (IL-10) from rat has been used to study the anti-allodynic effect of IL-10 in rat model.[1]
Biochem/physiol Actions
Interleukin-10 is an important regulator of the functions of lymphoid and myeloid cells. IL-10 can block the activation of cytokine synthesis and several accessory functions of macrophages. Human and mouse IL-10 share a 73% sequence homology. However, human IL-10 acts on both human and mouse target cells, while mouse IL-10 has species-specific activity. In mouse, the cellular sources of IL-10 consist of Th2 cells, activated fetal thymocytes, macrophages, keratinocytes, LY-1+ (CD5+), and normal B cells. In human, the cellular sources of IL-10 consist of CD4+ T cells and T cell clones, thymocytes, B cells, B cell lymphomas, macrophages, mast cell lines and keratinocytes. IL-10 stimulates the growth of stem cells, mast cells and thymocytes. IL-10 enhances cytotoxic T cell development, and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing the cell-type dependent expression of either angiogenic or angiostatic factors.
Interleukin-10 regulates lymphoid and myeloid cell functions. It blocks the activation of cytokine synthesis and several accessory functions of macrophages. IL-10 enhances cytotoxic T cell development and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing cell-type dependent expression of either angiogenic or angiostatic factors.
Interleukin-10 regulates lymphoid and myeloid cell functions; blocks the activation of cytokine synthesis and several accessory functions of macrophages; enhances cytotoxic T cell development and co-stimulates B cell differentiation and Ig secretion.
Physical form
Lyophilized from a 0.2 μm filtered in 20 mM Tris, 0.1 M sodium chloride containing 50 μg of bovine serum albumin per 1 μg of cytokine.
Analysis Note
The biological activity is measured in a cell proliferation assay using the murine mast cell line, MC/9.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
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Byung-Sang Lee et al.
Journal of Korean medical science, 28(2), 308-314 (2013-02-13)
We examined the possible anti-inflammatory mechanisms of gabapentin in the attenuation of neuropathic pain and the interaction between the anti-allodynic effects of gabapentin and interleukin-10 (IL-10) expression in a rat model of neuropathic pain. The anti-allodynic effect of intrathecal gabapentin
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Plasmacytoid dendritic cells (pDCs) display altered immune-phenotype in multiple sclerosis (MS) patients and are found actively recruited in postmortem MS brain lesions, implying that their immune regulation may represent an important aspect of MS pathogenesis. Because of the reported Toll-like
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