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Merck

I1774

Iturin A from Bacillus subtilis

≥95% (HPLC), suitable for microbiological culture

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Informacje o tej pozycji

Numer CAS:
52229-90-0
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD01094135

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Nazwa produktu

Iturin A from Bacillus subtilis, ≥95% (HPLC)

biological source

Bacillus subtilis

Quality Level

200

assay

≥95% (HPLC)

form

powder

technique(s)

microbiological culture: suitable

color

white to yellow

solubility

ethanol: soluble 9.80-10.20 mg/mL

antibiotic activity spectrum

fungi

mode of action

cell membrane | interferes

storage temp.

2-8°C

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Ta pozycja
L1294A9430L4040
Iturin A from Bacillus subtilis ≥95% (HPLC)

Sigma-Aldrich

I1774

Iturin A from Bacillus subtilis

Lactoferrin human recombinant, expressed in rice, Iron saturated, ≥90% (SDS-PAGE)

Sigma-Aldrich

L1294

Lactoferrin human

Bovine Serum Albumin heat shock fraction, low endotoxin, pH 7, ≥98%

Sigma-Aldrich

A9430

Bovine Serum Albumin

Lactoferrin human recombinant, expressed in rice, Partially iron saturated, ≥90% (SDS-PAGE)

Sigma-Aldrich

L4040

Lactoferrin human

form

powder

form

powder

form

lyophilized powder

form

powder

assay

≥95% (HPLC)

assay

≥90% (SDS-PAGE), ≥90% (biuret)

assay

≥98%

assay

≥70% protein basis (Bradford), ≥90% (SDS-PAGE)

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

technique(s)

ELISA: suitable, microbiological culture: suitable

technique(s)

microbiological culture: suitable

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

ethanol: soluble 9.80-10.20 mg/mL

solubility

-

solubility

water: soluble (40 mg/ml)

solubility

H2O: soluble 10 mg/mL

color

white to yellow

color

-

color

-

color

-

Application

Iturin A was used in the study of Bacillomycin D (an iturin with antifungal activity against Aspergillus flavus).[1]

Biochem/physiol Actions

IturinA exhibits strong antifungal activity against pathogenic yeast and fungi.[2] It interacts with the cytoplasmic membrane of the target cell forming ion conducting pores[3]. Its mode of action could be attributed to its interaction with sterols and phospholipids. The compound causes the release of exo-vesicles from human erythrocytes.

Other Notes

A family of lipopeptides characterized by a heptapeptide cyclized with a C13-C17 β-amino fatty acid. Composed mainly of C14-C15 β-amino acids.
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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number
0000477758
0000454815
0000454815
0000388861
0000388861

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Scott W Pryor et al.
Journal of agricultural and food chemistry, 55(23), 9530-9536 (2007-10-24)
Partial least squares (PLS) regression modeling was used to relate the antifungal activity of Bacillus subtilis solid-state fermentation extracts to the individual high-performance liquid chromatography (HPLC) peaks from those extracts. A model was developed that predicted bioassay inhibition based on
R Maget-Dana et al.
Toxicology, 87(1-3), 151-174 (1994-02-28)
Iturins are a family of lipopeptides extracted from the culture media of various strains of Bacillus subtilis. These amphiphilic compounds are characterized by a peptide ring of seven amino acid residues including an invariable D-Tyr2, with the constant chiral sequence
M A Klich et al.
Mycopathologia, 127(2), 123-127 (1994-08-01)
The removal of many synthetic fungicides from the market has created a demand for new, environmentally safe fungicides. Iturin A, a cyclic lipopeptide produced by Bacillus subtilis, has strong antifungal properties and low mammalian toxicity. To determine the efficacy of
Thimon, L., et al.
Cytobios, 79, 96-96 (1994)
Nopporn Thasana et al.
FEBS letters, 584(14), 3209-3214 (2010-06-15)
Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common alpha-amino acids, L-Asn-1, D-Tyr-2, D-Asn-3, L-Gln-4, L-Pro-5, D-Asn-6, L-Ser-7 and the unique beta-amino acid-8 present in the
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Numer pozycji handlu globalnego

SKUNUMER GTIN
I1774-1MG04061833848098
I1774-5MG04061833848104

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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