H108

Hemicholinium-3

≥95% (HPLC), acetylcholine synthesis inhibitor, solid

• Synonim(y): 2,2′-(4,4′-Biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium bromide)
• Wzór empiryczny (zapis Hilla): C₂₄H₃₄Br₂N₂O₄
• Numer CAS: 312-45-8
• Masa cząsteczkowa: 574.35
• NACRES: NA.77
• PubChem Substance ID: 24278169
• UNSPSC Code: 12352200
• EC Number: 206-227-3
• MDL number: MFCD00011978
• Beilstein/REAXYS Number: 5704458
• Assay: ≥95% (HPLC)
• Form: solid

Właściwości

• Nazwa produktu: Hemicholinium-3, solid, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• color: white
• solubility: ethanol: 1.3 mg/mL, H₂O: 10 mg/mL
• SMILES string: [Br-].[Br-].C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)-c3ccc(cc3)C4(O)C[N+](C)(C)CCO4
• InChI: 1S/C24H34N2O4.2BrH/c1-25(2)13-15-29-23(27,17-25)21-9-5-19(6-10-21)20-7-11-22(12-8-20)24(28)18-26(3,4)14-16-30-24;;/h5-12,27-28H,13-18H2,1-4H3;2*1H/q+2;;/p-2
• InChI key: OPYKHUMNFAMIBL-UHFFFAOYSA-L

Opis

Application

Hemicholinium-3 has been used in the preparation of Krebs-HC-3 buffer to study its effects on choline uptake and choline acetyltransferase activity in differentiated human neuroblastoma (SK-N-SH) cells.

Biochem/physiol Actions

Hemicholinium-3 plays a role in blocking the neuronal choline uptake thereby inhibiting acetylcholine synthesis in the brain.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331,H315,H319,H335
• pcodes: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges