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E6627
cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt
synthetic (organic), ≥99% (capillary GC), 5-Lipoxygenase inhibitor, film or powder
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 279,00 zł | |
| 25 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1020,00 zł |
Informacje o tej pozycji
Wzór liniowy:
CH3(CH2CH=CH)5(CH2)3CO2Na
Numer CAS:
Masa cząsteczkowa:
324.43
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.77
MDL number:
279,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt, ≥99% (capillary GC)
biological source
synthetic (organic)
Quality Level
assay
≥99% (capillary GC)
form
film or powder
color
white to off-white
solubility
methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
shipped in
dry ice
storage temp.
−20°C
SMILES string
[Na].CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
Powiązane kategorie
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Ta pozycja | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source fish oil | biological source algae | biological source fish oil |
| assay ≥99% (capillary GC) | assay ≥99% | assay ≥98% | assay ≥98.5% (GC) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form film or powder | form liquid | form liquid | form - |
| solubility methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow | solubility methanol: 50 mg/mL, clear, colorless | solubility - | solubility - |
| shipped in dry ice | shipped in - | shipped in dry ice | shipped in - |
General description
Eicosapentaenoic acid (EPA)/timnodonic acid is an omega-3 polyunsaturated fatty acid (PUFA). This long-chain fatty acid is mainly found in fish oil.
Application
cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt has been used:
- to study its effect on the pathology of lupus in drug-induced and spontaneous mouse models
- to pretreat mouse alveolar macrophages to study the effect/relationship between amiodarone and eicosapentaenoic acid (EPA) concerning the cytokine release
- to examine if pharmacological correction with EPA supplementation might restore autophagic flux and reduce renal lipotoxicity in mice
Biochem/physiol Actions
5-Lipoxygenase inhibitor; reduces thromboxane A2 production.
Eicosapentaenoic acid (EPA) possesses anti-hyperglycemic, anti-oxidant, anti-hyperlipidemic, and anti-inflammatory properties. It aids in improving vasoreactivity. EPA is capable of suppressing vascular smooth muscle proliferation. It ameliorates pulmonary hypertension by preventing Fyn kinase activity. EPA exhibits a beneficial effect on lipid metabolism. It is used to treat hypercholesterolemia and atherosclerosis.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Y Futamura
Japanese journal of pharmacology, 69(4), 335-341 (1995-12-01)
I studied the effect of amiodarone, a cationic amphiphilic drug, on the cytokine release and protein kinase C (PKC) activity of mouse alveolar macrophages. In addition, I examined the relationship between amiodarone and eicosapentaenoic acid (EPA) with respect to the
Lin Hai Kurahara et al.
Journal of molecular and cellular cardiology, 148, 50-62 (2020-09-06)
Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by pulmonary arterial vasoconstriction and remodeling. Src family tyrosine kinases, including Fyn, play critical roles in vascular remodeling via the inhibition of STAT3 signaling. EPA is known to inhibit Fyn kinase
Azusa Kobayashi et al.
Frontiers in immunology, 12, 650856-650856 (2021-07-03)
Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with the development of autoimmune diseases. However, the mechanism by which fatty acid composition influences autoimmune responses remains unclear. To determine whether the fatty acid composition of diet modulates
Yong-Ping Zhang et al.
Prostaglandins, leukotrienes, and essential fatty acids, 136, 85-94 (2017-08-06)
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been reported to prevent neurodegenerative diseases such as Alzheimer's disease (AD) in both experimental and clinical/epidemiological studies. However, whether DHA and EPA from natural products exert
Takeshi Yamamoto et al.
Autophagy, 17(7), 1700-1713 (2020-06-18)
Recently, we identified a novel mechanism of lipotoxicity in the kidney proximal tubular cells (PTECs); lipid overload stimulates macroautophagy/autophagy for the renovation of plasma and organelle membranes to maintain the integrity of the PTECs. However, this autophagic activation places a
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| E6627-25MG | 04061832785394 |
| E6627-5MG | 04061833604595 |
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