D9766

Dipyridamole

≥98% (HPLC), powder, phosphodiesterase V inhibitor

• Synonim(y): NSC 515776, NSC 619103
• Wzór empiryczny (zapis Hilla): C₂₄H₄₀N₈O₄
• Numer CAS: 58-32-2
• Masa cząsteczkowa: 504.63
• Numer WE: 200-374-7
• Numer MDL: MFCD00010555
• Kod UNSPSC: 41106305
• Identyfikator substancji w PubChem: 24277705
• NACRES: NA.77

Właściwości

• Nazwa produktu: Dipyridamole, ≥98% (HPLC)
• Próba: ≥98% (HPLC)
• Formularz: powder
• kolor: yellow
• mp: 165-166 °C (lit.)
• rozpuszczalność: DMSO: soluble; ethanol: soluble
• inicjator: Boehringer Ingelheim
• temp. przechowywania: room temp
• ciąg SMILES: OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
• InChI: 1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
• Klucz InChI: IZEKFCXSFNUWAM-UHFFFAOYSA-N
• informacje o genach: human ... CYP1A2(1544) , PDE10A(10846) , PDE1A(5136) , PDE1B(5153) , PDE1C(5137) , PDE2A(5138) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE6A(5145) , PDE6B(5158) , PDE6C(5146) , PDE6D(5147) , PDE6G(5148) , PDE6H(5149) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622) , PDE9A(5152) , SLC29A1(2030) ; mouse ... Slc29a1(63959)

Opis

Opis ogólny

Dipyridamole prevents cellular uptake of adenosine.[1] It functions as an equilibrative nucleoside transporter 1 (ENT1) inhibitor.[2]

Zastosowanie

Dipyridamole has been used:

• to perform in vitro growth inhibition assay(40)
• to determine its ability to prevent uterine myometrial contractions(41)
• to determine its effects on nicotinamide adenine dinucleotide (NAD+)-induced increase in intracellular adenosine triphosphate (ATP) levels(42)
• to prevent nicotinamide riboside (NR)-induced axonal protection(43)

Działania biochem./fizjol.

Selective inhibitor of phosphodiesterase V (PDE 5); potent coronary vasodilator drug; adenosine transport inhibitor; inhibitor of platelet aggregation.

Cechy i korzyści

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves