The solution stability at -80°C is not determined.
D2926
Diphenyleneiodonium chloride
≥98%, Nitric oxide synthetase inhibitor, powder
Synonim(y):
DPI, Dibenziodolium chloride
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10 MG
759,00 zł
50 MG
3080,00 zł
759,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C12H8ClI
Numer CAS:
Masa cząsteczkowa:
314.55
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Diphenyleneiodonium chloride, ≥98%
SMILES string
[Cl-].[I+]1c2ccccc2-c3ccccc13
InChI
1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
InChI key
FCFZKAVCDNTYID-UHFFFAOYSA-M
assay
≥98%
form
powder
mp
278 °C
solubility
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
storage temp.
room temp
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
mouse ... Pik3r1(18708)
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Ta pozycja | |||
|---|---|---|---|
| form powder | form crystalline solid | form powder | form powder |
| assay ≥98% | assay ≥97% (HPLC) | assay ≥98% (HPLC) | assay ≥98% |
| Quality Level 300 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| storage temp. room temp | storage temp. −20°C | storage temp. room temp | storage temp. room temp |
| solubility DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow | solubility DMSO: 5 mg/mL | solubility deionized water: ≥20 mg/mL | solubility chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow |
| mp 278 °C | mp - | mp - | mp - |
Application
Diphenyleneiodonium chloride has been used as an NOX inhibitor:
- to study its effects on the reactive oxygen species (ROS) levels and also its inhibitory effects on killing tumor cells by neutrophils isolated from clinical malignant pleural effusion (MPE) samples[1]
- as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor to confirm the variation in inflammation was secondary to overproduction of reactive oxygen species (ROS) in cells treated with doxorubicin (DOX) + flagellin (FL)[2]
- as an NADPH oxidase (NOX) inhibitor to study its effects on palmitate (PA)-induced sphere-forming ability of HepG2 (hepatocellular carcinoma) cells[3]
Biochem/physiol Actions
A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.
A potent reversible nitric oxide synthetase inhibitor from macrophages and endothelial cells.
Diphenyleneiodonium (DPI) can affect mitochondrial function. DPI can block neuron degeneration in Parkinson′s disease. It provides neuroprotection following focal cerebral ischemia. DPI can induce a chemo-quiescence phenotype in cancer stem-like cells, effectively inhibiting their proliferation.[4]
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Produkty
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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Will the solution stability of Product No. D2926, Diphenyleneiodonium chloride be extended if kept at -80°C?
1 answer-
Helpful?
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How should Product No. D2926, Diphenyleneiodonium chloride be dissolved?
1 answer-
Product D2926 is soluble in DMSO at a concentration of 10 mg/mL, with strong heating. It is also easily soluble at 2.4 mg/mL in DMSO, in 0.1N NaOH (at 0.5 mg/mL), in 0.1N HCl (at 0.2 mg/mL), in ethanol (at 0.2 mg/mL) or in water (0.2 mg/mL). Stock solutions can be prepared at 10 mM in DMSO, according to O'Donnell, V. B., et al., Studies on the Inhibitory Mechanism of Iodonium Compounds with Special Reference to Neutrophil NADPH Oxidase. Biochem. J., 290(pt 1), 41-49 (1993), or at 3 x 10-8 to 3 x 10-6 M in a 5% glucose solution according to Wang, Y. X., et al., Inhibitory Actions of Diphenyleneiodonium on Endothelium-dependent Vasodilatations In Vitro and In Vivo. Br. J.Pharmacol., 110(3), 1232-1238 (1993).
Helpful?
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Product No. D2926 is an inhibitor of nitric oxide synthase (NOS). Does Sigma-Aldrich offer any other NOS inhibitors?
1 answer-
We do offer other inhibitors of NOS, such as Product Nos. M7033 (NG-Methyl-L-arginine) and A7009 (Aminoguanidine).
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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What is the solution stability of Product No. D2926, Diphenyleneiodonium chloride?
1 answer-
A stock solution of D2926 in DMSO can be stored at -20°C for up to 3 months.
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