D0899

Diazepam

≥98% (TLC), powder, GABAA receptor ligand

• Synonim(y): 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one, Ro 5-2807
• Wzór empiryczny (zapis Hilla): C₁₆H₁₃ClN₂O
• Numer CAS: 439-14-5
• Masa cząsteczkowa: 284.74
• Numer WE: 207-122-5
• Numer MDL: MFCD00057323
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24893306
• NACRES: NA.77

Właściwości

• product name: Diazepam,
• Postać: powder
• kontrola substancji: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• rozpuszczalność: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL; DMF: soluble; H₂O: slightly soluble; ethanol: soluble
• inicjator: Roche
• ciąg SMILES: CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13
• InChI: 1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
• Klucz InChI: AAOVKJBEBIDNHE-UHFFFAOYSA-N
• informacje o genach: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) ; rat ... Gabra1(29705) , Gabra2(29706)

Opis

Zastosowanie

Diazepam has been used:

• as an anxiolyte in pilocarpine protocol.
• in multi-electrode array (MEA) technology
• as a marker for human serum albumin

Działania biochem./fizjol.

Diazepam is a benzodiazepine anxiolytic agent. It serves as a prototype ligand for the GABAA receptor benzodiazepine modulatory site.

Diazepam is often used as a sedative. Its metabolism involves cytochrome P450 (CYP) 2C19 and 3A4. Diazepam has immediate action upon administration.

Cechy i korzyści

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H301 + H311,H410
• Zwroty wskazujące środki ostrożności: P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312 - P361 + P364
• Klasyfikacja zagrożeń: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 1
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Faceshields, Gloves