C4024

Carbamazepine

≥98% (HPLC), powder, sodium channel inhibitor

• Synonim(y): 5H-Dibenz[b,f]azepine-5-carboxamide
• Wzór empiryczny (zapis Hilla): C₁₅H₁₂N₂O
• Numer CAS: 298-46-4
• Masa cząsteczkowa: 236.27
• UNSPSC Code: 12352200
• eCl@ss: 34051404
• PubChem Substance ID: 57654002
• NACRES: NA.77
• EC Number: 206-062-7
• MDL number: MFCD00005073
• Form: powder

Właściwości

• Nazwa produktu: Carbamazepine, powder
• form: powder
• Quality Segment: 100
• mp: 191-192 °C (lit.)
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL, H₂O: insoluble, ethanol: soluble, propylene glycol: soluble
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: NC(=O)N1c2ccccc2C=Cc3ccccc13
• InChI: 1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
• InChI key: FFGPTBGBLSHEPO-UHFFFAOYSA-N
• Gene Information: human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), PRNP(5621), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) ; rat ... Scn2a1(24766), Scnn1a(25122), Scnn1g(24768), Slc6a1(79212)

Opis

Application

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration. It has also been used to find out its effects on spontaneous seizures in rats.

Biochem/physiol Actions

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.

Anticonvulsant; ligand for the GABA_A receptor benzodiazepine modulatory site. Sodium channel inhibitor.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H317,H334,H336,H360FD
• pcodes: P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3
• target_organs: Central nervous system
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves