C3042

Corticotropin Releasing Factor human, rat

≥95% (HPLC), powder

• Synonim(y): CRF, CRH
• Wzór empiryczny (zapis Hilla): C₂₀₈H₃₄₄N₆₀O₆₃S₂
• Numer CAS: 86784-80-7
• Masa cząsteczkowa: 4757.45
• Numer MDL: MFCD00213806
• Kod UNSPSC: 12352200
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human; rat
• Poziom jakości: 200
• Próba: ≥95% (HPLC)
• Formularz: powder
• masa cząsteczkowa: 4757.45
• warunki przechowywania: (Keep container tightly closed in a dry and well-ventilated place)
• metody: activity assay: suitable
• rozpuszczalność: water: 1.00-1.04 mg/mL, colorless
• numer dostępu UniProt: P06850
• temp. przechowywania: −20°C
• Klucz InChI: VXFVFWFSJFSXHN-FAUHKOHMSA-N
• informacje o genach: human ... CRH(1392)

Opis

Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

Opis ogólny

The corticotropin-releasing factor is a 41-amino-acid polypeptide.[1] It is expressed in neurons, the hypothalamus, and the amygdala.[2]

Research area: Neuroscience

Zastosowanie

Corticotropin Releasing Factor human, rat has been used:

• as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants[3]
• as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells[4]
• in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture[5]
• in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus[6]

Działania biochem./fizjol.

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

Corticotropin-releasing factor modulates stress responses.[7][1] It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.[8]Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders.[9] Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.[10]

Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.

Inne uwagi

Lyophilized from 0.1% TFA in H2O

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)