B2515

L-Buthionine-sulfoximine

≥97% (TLC)

• Synonim(y): L-BSO
• Wzór empiryczny (zapis Hilla): C₈H₁₈N₂O₃S
• Numer CAS: 83730-53-4
• Masa cząsteczkowa: 222.31
• Beilstein: 2367136
• Numer MDL: MFCD00067000
• Kod UNSPSC: 12352202
• Identyfikator substancji w PubChem: 24278263
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Próba: ≥97% (TLC)
• Postać: powder
• mp: 224-226 °C
• rozpuszczalność: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• ciąg SMILES: CCCCS(=N)(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
• Klucz InChI: KJQFBVYMGADDTQ-CVSPRKDYSA-N
• informacje o genach: human ... GCLC(2729) , GCLM(2730)

Opis

Zastosowanie

L-Buthionine-sulfoximine has been used:

• as a selective activator for the induction of ferroptosis in rat apoptotic cells
• as an inhibitor of γ-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barley
• as a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1β expression in murine alveolar macrophages

Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

Działania biochem./fizjol.

Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)