AV32753

Anti-OLIG2 Antibody

rabbit polyclonal

• Synonim(y): Anti-Oligodendrocyte lineage transcription factor 2
• UNSPSC Code: 12352203
• NACRES: NA.41
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: 4

Właściwości

• Nazwa produktu: Anti-OLIG2 (AB1) antibody produced in rabbit, affinity isolated antibody
• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 32 kDa
• species reactivity: human
• concentration: 0.5 mg - 1 mg/mL
• technique(s): immunohistochemistry: suitable, western blot: suitable
• NCBI accession no.: NP_005797
• UniProt accession no.: Q13516
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... OLIG2(10215)

Opis

General description

Oligodendrocyte lineage transcription factor 2 (OLIG2), a basic helix-loop-helix transcription factor, is an essential regulator of ventral neuroectodermal progenitor cell fate and is required for oligodendrocyte and motor neuron development. OLIG2 is a universal marker of diffuse gliomas including oligodendroglioma, astrocytoma, glioblastoma, and mixed glioma.

Rabbit polyclonal anti-OLIG2 antibody reacts with chicken, human, and mouse oligodendrocyte lineage transcription factor 2 transcription factors.

Immunogen

Synthetic peptide directed towards the C-terminal region of Human OLIG2

Application

Rabbit Anti-OLIG2 (AB1) antibody can be used for western blot applications at a concentration of 0.5 μg/ml.

Rabbit polyclonal anti-OLIG2 antibody is used to tag oligodendrocyte lineage transcription factor 2 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of oligodendrocyte lineage transcription factor 2 in ventral neuroectodermal progenitor cell fate and as a diffuse glioma marker protein.

Biochem/physiol Actions

OLIG2 is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. OLIG2 is an essential regulator of ventral neuroectodermal progenitor cell fate. It is associated with T-cell acute lymphoblastic leukemia due to a chromosomal translocation t(14;21)(q11.2;q22). OLIG2 might play a role in learning deficits associated with Down syndrome.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: AAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGF

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable