A3352
Acyl-coenzyme A Synthetase from Pseudomonas sp.
≥2 units/mg protein
Synonim(y):
Acid: CoA ligase (AMP-forming)
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Informacje o tej pozycji
Numer CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-747-5
MDL number:
Specific activity:
≥2 units/mg protein
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Ta pozycja | |||
|---|---|---|---|
| specific activity ≥2 units/mg protein | specific activity ≥3 units/mg protein | specific activity ≥3 units/mg protein | specific activity ≥100 units/mg solid |
| form powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| shipped in dry ice | shipped in - | shipped in - | shipped in - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
General description
Acyl-coenzyme A synthetase belongs to adenylate-forming enzymes superfamily. It has a conserved adenosine triphosphate/adenosine monophosphate (ATP/AMP) binding motif.
Application
Acyl-coenzyme A Synthetase may be used to study fatty acid metabolism and lipid metabolism. It has been used to study its interaction with fatty acid transport proteins, which has been found to be involved in the efficient cellular uptake of long-chain fatty acids in adipocytes [1].
Acyl-coenzyme A (coA) synthetase from Pseudomonas sp. has been used:
- as ligase in the synthesis of mevalonate derivatives of adenosine triphosphate (ATP)
- in in vitro fatty acylation assays
- in the synthesis of (14C)Vernoloyl-CoA (Va-CoA),(3) bisphosphonates derivatives of ATP(4) and (3H)Palmitate-CoA
Biochem/physiol Actions
Acyl coenzyme A synthetase proteins are involved in regulating and facilitating long-chain fatty acid transport in mammalian cells [1].
Acyl-coenzyme A (CoA) synthetase (ACS) enzyme catalyzes a two-step thioesterification reaction involving the conversion of free fatty acids (FAs) to CoA esters. The substrate for ACS varies from two carbon to 26 carbon FAs. It is involved in the activation of FAs for lipid metabolism and enables FA to participate in various cellular metabolic pathways.
Other Notes
One unit will form 1.0 μmole of AMP and oleoyl coenzyme A from ATP and oleate at pH 8.1 at 25 °C in the presence of Coenzyme A.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Michael Veit et al.
Methods in molecular biology (Clifton, N.J.), 446, 163-182 (2008-04-01)
Palmitoylation or S-acylation is the post-translational attachment of fatty acids to cysteine residues and is common among integral and peripheral mem brane proteins. Palmitoylated proteins have been found in every eukaryotic cell type examined (yeast, insect, and vertebrate cells), as
Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
Kochan G, et al.
Journal of Molecular Biology, 388(5), 997-1008 (2009)
Teresa J Stradomska
Postepy biochemii, 57(2), 183-190 (2011-09-15)
Peroxisomes, classical compartments of eucaryotic cells have significant functions in cellular metabolism, which beta-oxidation fatty acids and detoxification of H2O2 are the most important biochemical process. Defects in genes encoding for peroxisomal proteins result in biochemical malfunctioning of these organelles
Hongjie Zhang et al.
Nature cell biology, 13(10), 1189-1201 (2011-09-20)
Metazoan internal organs are assembled from polarized tubular epithelia that must set aside an apical membrane domain as a lumenal surface. In a global Caenorhabditis elegans tubulogenesis screen, interference with several distinct fatty-acid-biosynthetic enzymes transformed a contiguous central intestinal lumen
Physiological role of acyl coenzyme A synthetase homologs in lipid metabolism in Neurospora crassa
Roche CM, et al.
Eukaryotic Cell, 12(9), 1244-1257 (2013)
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| A3352-10UN | 04061833627624 |
| A3352-1UN | 04061833627648 |
| A3352-5UN | 04061833627662 |
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