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Merck

81357

Sigma-Aldrich

Poly(Glu, Tyr) sodium salt

suitable for ligand binding assays, Mol wt 20,000-50,000

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About This Item

Numer CAS:
Numer MDL:
Kod UNSPSC:
12352209
NACRES:
NA.26

product name

Poly(Glu, Tyr) sodium salt, mol wt 20,000-50,000, Glu:Tyr 4:1

Poziom jakości

Postać

powder

proporcje

Glu:Tyr (4:1)

masa cząsteczkowa

20,000-50,000

metody

ligand binding assay: suitable

kolor

white to off-white

temp. przechowywania

−20°C

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Działania biochem./fizjol.

Poly(Glu,Tyr) (poly(Glu,Tyr) 4:1 random copolymer) is used as a substrate for the evaluation of protein tyrosine kinase(s).
Poly(Glu,Tyr) 4:1 is a polyamino acid used in the manufacture of electrochemical biosensors for detection of reactions such as Fenton induced tyrosine oxidation.

Inne uwagi

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Masanobu Chiku et al.
Biosensors & bioelectronics, 26(1), 235-240 (2010-07-17)
In this report, we determined protein tyrosine kinase (PTKs) activity in human epidermoid carcinoma cells (A431) by employing a novel electrochemical method using boron-doped diamond (BDD) electrodes that enables the electrochemical oxidation of tyrosine (Tyr), phosphorylated Tyr (Tyr-P) and sulfated
Morten R Clausen et al.
Journal of agricultural and food chemistry, 56(18), 8692-8698 (2008-09-02)
Oxidation of 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) by lactoperoxidase was found to be inhibited by tyrosine-containing random amino acid copolymers but not by tyrosine. Both electrostatic effects and polymer size were found to be important by comparison of negatively and positively charged copolymers
Na Qu et al.
Biosensors & bioelectronics, 26(5), 2292-2296 (2010-11-03)
A simple and sensitive electrochemical biosensor was used to detect tyrosine oxidation induced by hydroxyl radicals generated by Fenton reaction (Fe(2+)/H(2)O(2)). Poly(glu, tyr) (4:1) peptides were immobilized on indium tin oxide (ITO) electrode surface via layer-by-layer assembly technique, and Os(bpy)(3)(2+)-mediated
D M Williams et al.
The Journal of biological chemistry, 275(49), 38127-38130 (2000-09-28)
Protein-tyrosine kinases contain a catalytic loop Arg residue located either two or four positions downstream of a highly conserved Asp residue. In this study, the role of this Arg (Arg-318) in the protein-tyrosine kinase C-terminal Src kinase (Csk) was investigated.
Edit Varkondi et al.
Journal of receptor and signal transduction research, 25(1), 45-56 (2005-06-18)
Receptor tyrosine kinases (PTKs) play key roles in the pathogenesis of numerous human diseases, including cancer, and therefore PTK inhibitors are currently under intense investigation as potential drug candidates. PTK inhibitor screening data are, however, poorly comparable because of the

Produkty

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