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Sigma-Aldrich

Phalloidin–Atto 390

BioReagent, suitable for fluorescence, ≥90% (HPLC)

Synonim(y):

Atto 390–Phalloidin

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About This Item

Kod UNSPSC:
12352116
NACRES:
NA.32

linia produktu

BioReagent

Próba

≥90% (HPLC)

producent / nazwa handlowa

ATTO-TEC GmbH

λ

in methanol

absorpcja UV

λ: 382-388 nm Amax

przydatność

suitable for fluorescence

temp. przechowywania

−20°C

Opis ogólny

Atto 390 Phalloidin is a novel fluorescent label with a coumarin structure. The dye is intended for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Characteristic features of the label are high fluorescence quantum yield, large Stokes-shift, good photostability and low molecular weight.Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10–8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours.

Zastosowanie

Fluorescent conjugates of phalloidin, rhodamine-phalloidin staining reagents, such as Phalloidin–Atto 390 are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.

Informacje prawne

This product is for Research use only. In case of intended commercialization, please contact the IP-holder (ATTO-TEC GmbH, Germany) for licensing.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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Sigma-Aldrich

P1951

Phalloidin–Tetramethylrhodamine B isothiocyanate

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