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Merck

427M-9

Sigma-Aldrich

p27Kip1 (SX53G8) Mouse Monoclonal Antibody

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About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

mouse

Poziom jakości

100
500

białko sprzężone

unconjugated

forma przeciwciała

culture supernatant

rodzaj przeciwciała

primary antibodies

klon

SX53G8, monoclonal

opis

For In Vitro Diagnostic Use in Select Regions (See Chart)

Postać

buffered aqueous solution

reaktywność gatunkowa

human

opakowanie

vial of 0.1 mL concentrate (427M-94)
vial of 0.5 mL concentrate (427M-95)
bottle of 1.0 mL predilute (427M-97)
vial of 1.0 mL concentrate (427M-96)
bottle of 7.0 mL predilute (427M-98)

producent / nazwa handlowa

Cell Marque

metody

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

izotyp

IgG1κ

kontrola

tonsil

Warunki transportu

wet ice

temp. przechowywania

2-8°C

wizualizacja

nuclear

informacje o genach

Opis ogólny

p27 is a cyclin-dependent kinase inhibitor which regulates progression from G1 to S phase by binding and inhibiting cyclin-dependent kinases. Low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, small breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, lymph node metastases in Papillary carcinoma of the Thyroid, and more aggressive phenotype in carcinoma of the cervix.

Jakość


IVD

IVD

IVD

RUO

Powiązanie

p27Kip1 Positive Control Slides, Product No. 427S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Postać fizyczna

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Uwaga dotycząca przygotowania

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Inne uwagi

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informacje prawne

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

V Esposito et al.
Cancer research, 57(16), 3381-3385 (1997-08-15)
Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. We investigated p27 protein expression in a series of 108 non-small
P Tan et al.
Cancer research, 57(7), 1259-1263 (1997-04-01)
Breast carcinomas < or = 1 cm in size (T1a,b) are being detected more frequently as a result of screening. Because traditional prognostic parameters are either lacking (tumor size) or rare (nodal metastases), a marker(s) is needed to identify the
Carolina Armengol et al.
Journal of hepatology, 38(5), 591-597 (2003-04-26)
Alterations in p27(Kip1) (p27) and cyclin E (cycE) expression are found in tumors and are related to poor prognosis. This study assesses the role of these cell cycle regulators in the development of recurrence after surgical resection in 46 cirrhotic
A Haitel et al.
Urology, 58(3), 477-481 (2001-09-11)
To determine whether p21, p27, and pRb can predict disease progression in clear cell renal cell carcinoma. The expression of three negative regulators of the cell cycle, the retinoblastoma gene product (pRb), the WAF1/Cip1 gene product (p21), and the Kip1
R V Lloyd et al.
The American journal of pathology, 154(2), 313-323 (1999-02-23)
p27kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family. p27 expression is regulated by cell contact inhibition and by specific growth factors, such as transforming growth factor (TGF)-beta. Since the cloning of the p27 gene in

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