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Dokumenty

321R-2

Sigma-Aldrich

PLAP (EP194) Rabbit Monoclonal Primary Antibody

Synonim(y):

Placental Alkaline Phosphatase

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About This Item

Kod UNSPSC:
12352203

pochodzenie biologiczne

rabbit

białko sprzężone

unconjugated

forma przeciwciała

culture supernatant

rodzaj przeciwciała

primary antibodies

klon

EP194, monoclonal

opis

For In Vitro Diagnostic Use in Select Regions

Postać

buffered aqueous solution

reaktywność gatunkowa

human

opakowanie

vial of 0.1 mL concentrate (321R-24)
vial of 0.1 mL concentrate Research Use Only (321R-24-RUO)
vial of 0.5 mL concentrate (321R-25)
vial of 1.0 mL concentrate (321R-26)
vial of 1.0 mL concentrate Research Use Only (321R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (321R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (321R-27)
vial of 7.0 mL pre-dilute ready-to-use (321R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (321R-28-RUO)

producent / nazwa handlowa

Cell Marque™

metody

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

izotyp

IgG

kontrola

placenta

Warunki transportu

wet ice

temp. przechowywania

2-8°C

wizualizacja

cytoplasmic

informacje o genach

human ... ALPP(250)

Powiązane kategorie

Opis ogólny

Placental alkaline phosphatase (PLAP) is normally produced by primordial germ cells and syncytiotrophoblasts, and the detection of its expression has been useful in identifying germ cell tumors. Anti-PLAP antibody immunoreacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease. Complete hydatidiform mole shows strong expression of hCG and weak expression of PLAP. Weak hCG and strong PLAP expression is found in partial hydatidiform mole. Choriocarcinoma presents strong expression of hCG and weak expression of hPL and PLAP.8 In addition to its role as a germ cell marker, PLAP may also be used as a myogenic marker in identifying soft tissue tumors.

Jakość


IVD
IVD
IVD
RUO

Powiązanie

PLAP Positive Control Slides, Product No. 321S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Postać fizyczna

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Uwaga dotycząca przygotowania

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Inne uwagi

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informacje prawne

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Fenghua Wang et al.
The American journal of surgical pathology, 33(10), 1529-1539 (2009-07-04)
Extragonadal yolk sac tumors (YSTs; primary and metastatic) are rare but are malignant germ cell tumors. Pathologic diagnosis of extragonadal YSTs can be challenging without immunohistochemical markers but markers used for diagnosing these tumors such as placental-like alkaline phosphatase (PLAP)
Yuping Gao et al.
International journal of clinical and experimental pathology, 7(10), 6965-6972 (2014-11-18)
Primary central nervous system (CNS) germ cell tumors (GCTs) are a rare heterogeneous group of lesions, which the clinicopathological features have a marked degree of heterogeneity comparing with that of gonadal GCTs. Accurately diagnosing CNS GCTs might be extremely difficult
A Lösch et al.
Acta obstetricia et gynecologica Scandinavica, 75(8), 753-756 (1996-09-01)
The gestational trophoblastic disease summarizes all types of hydatidiform moles, placental site trophoblastic tumor and choriocarcinoma. It is of clinical relevance to distinguish between complete hydatidiform mole and partial hydatidiform mole to predict prognosis of recurrency of molar pregnancy and
Reda S Saad et al.
Applied immunohistochemistry & molecular morphology : AIMM, 11(2), 107-112 (2003-06-05)
A variety of primary and metastatic neoplasms can involve the anterior mediastinum and have similar radiographic or histologic appearances. We report an immunohistochemical (IHC) panel that includes CD5, placental-like alkaline phosphatase (PLAP), thyroid transcription factor 1 (TTF-1), cytokeratin (CK) 7
Jeffrey D Goldsmith et al.
The American journal of surgical pathology, 26(12), 1627-1633 (2002-12-03)
Placental alkaline phosphatase (PLAP) is normally produced by primordial germ cells and syncytiotrophoblasts, and the detection of its expression has been useful in the diagnosis of germ cell tumors. We have recently observed PLAP immunoreactivity in normal human adult and
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