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Dokumenty

203A-1

Sigma-Aldrich

Alpha-Fetoprotein Rabbit Polyclonal Antibody

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Wszystkie zdjęcia(1)

About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

100
500

białko sprzężone

unconjugated

forma przeciwciała

Ig fraction of antiserum

rodzaj przeciwciała

primary antibodies

klon

polyclonal

opis

For In Vitro Diagnostic Use in Select Regions (See Chart)

Postać

buffered aqueous solution

reaktywność gatunkowa

human

opakowanie

vial of 0.1 mL concentrate (203A-14)
vial of 0.5 mL concentrate (203A-15)
bottle of 1.0 mL predilute (203A-17)
vial of 1.0 mL concentrate (203A-16)
bottle of 7.0 mL predilute (203A-18)

producent / nazwa handlowa

Cell Marque™

metody

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

kontrola

fetal liver

Warunki transportu

wet ice

temp. przechowywania

2-8°C

wizualizacja

cytoplasmic

Opis ogólny

Alpha-fetoprotein (AFP) is a fetal tumor-associated polypeptide of the albuminoid gene family that binds and transports molecules in addition to many other proposed functions. This secretory protein is produced by the fetal yolk sac and liver but is found only in trace amounts in adult liver. AFP expression by immunohistochemistry is seen in hepatocellular carcinoma (HCC).
Positive staining with anti-AFP is seen in hepatocytes of the fetal liver and hepatoma. Since only traces of AFP are found in adult serum, elevated levels suggest either a benign or malignant lesion of the liver, a yolk sac carcinoma, or one of a few other tumors. Correspondingly, in conjunction with elevated serum levels, AFP has been immunohistochemically demonstrated in yolk sac tumors of gonadal and extragonadal sites, in hepatic malignancies, and in a few other neoplasms. The antigen is not denatured by most fixatives.

Jakość


IVD
IVD
IVD
RUO

Powiązanie

Alpha-Fetoprotein Positive Control Slides, Product No. 203S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Postać fizyczna

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Uwaga dotycząca przygotowania

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Inne uwagi

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informacje prawne

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Z D Goodman et al.
Cancer, 55(1), 124-135 (1985-01-01)
Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer showing features of both hepatocellular and biliary epithelial differentiation. In a review of 24 cases of this tumor, three histologic types were encountered. Four cases were Type I or "collision
Manual of Diagnostic Antibodies for Immunohistology, 9-10 (1999)
S H Tsung
Archives of pathology & laboratory medicine, 101(11), 572-574 (1977-11-01)
Immunofluorescence staining was applied to tissue with primary nonhepatic malignancies and/or their metastatic nodules in the liver. Tumor cells from the primary sites of two patients with carcinoma of the pancreas and one patient with Hodgkin's disease were found to
L M Roth et al.
Cancer, 37(2), 812-820 (1976-02-01)
Fourteen cases of yolk sac carcinoma, 10 occurring in gonadal, and four in extragonadal sites, seen at the Indiana University Hospitals from 1949 to 1974, were analyzed with respect to pathologic features, laboratory findings, and clinical course. Their histologic appearance
G K Jacobsen et al.
The American journal of surgical pathology, 5(3), 257-266 (1981-04-01)
The various histologic components of 39 germ cell tumors of the testis were studied with indirect labeled immunoperoxidase technique for the presence of the following tumor-associated antigens: alpha-fetoprotein (AFP), alpha 1-antitrypsin (A1AT), chorionic gonadotropin (HCG), specific pregnancy beta 1-glycoprotein (SP1)
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