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SMB00953

Sigma-Aldrich

2-Cyano-3,3-diphenylacrylic acid

≥95%

Synonim(y):

α-Cyano-β-diphenylacrylic acid, 2-Cyano-3,3-diphenylpropenoic acid

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About This Item

Wzór empiryczny (zapis Hilla):
C16H11NO2
Numer CAS:
10380-41-3
Masa cząsteczkowa:
249.26
Kod UNSPSC:
12352106
NACRES:
NA.22

pochodzenie biologiczne

synthetic

Poziom jakości

200

Próba

≥95%

Postać

solid

masa cząsteczkowa

249.26 g/mol

warunki przechowywania

(Tightly closed. Dry.)

metody

HPLC: suitable

kolor

white to off-white

temp. przechowywania

2-8°C

InChI

1S/C16H11NO2/c17-11-14(16(18)19)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10H,(H,18,19)

Klucz InChI

VSXIZXFGQGKZQG-UHFFFAOYSA-N

Opis ogólny

2-Cyano-3,3-diphenylacrylic acid (CDA) belongs to the class of α,β-unsaturated carboxylic acids. It is a primary metabolite of Octocrylene, an organic sunscreen that functions by absorbing UVB radiation and short UVA wavelengths, commonly utilized in cosmetics for sun protection. CDA exhibits prolonged systemic availability after dermal exposure which may accumulate in the body. It can be used to study skin-permeable selective cyclooxygenaswe-2 inhibitor composition, and to study hydrophilic components of cosmetic compositions, such as in sunscreen.

Zastosowanie

2-Cyano-.3-diphenylacrylic acid finds application in metabolomics, cosmetics and cancer research

Działania biochem./fizjol.

Within the human body, Octocrylene, a non-polar compound, undergoes metabolism to become a water-soluble metabolite 2-cyano-3,3-diphenylacrylic acid, which is excreted through the kidneys. A pilot study in the general population has consistently detected CDAA, and its levels have been linked to recent sunscreen application.

Cechy i korzyści

  • High quality compound suitable for multiple research applications
  • Compatible with a wide variety of chromatographic and spectrometry techniques

Inne uwagi

For additional information on our range of Biochemicals, please complete this form.
This product is intended for research purposes only, and it is not meant for human consumption.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number
0000185453
0000105042

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Julia Hiller et al.
Environment international, 132, 105068-105068 (2019-08-31)
Chemical UV filters are common components in sunscreens and cosmetic products and used to protect the skin against harmful effects of sunlight like sunburn. However, the effectiveness of sunscreens in the prevention of skin cancer is in some parts still
Daniel Bury et al.
Analytical chemistry, 90(1), 944-951 (2017-12-01)
Octocrylene (OC) is an emerging UV filter, which is used in the majority of sunscreens as well as other personal care products (PCP) and consumer products. Its presence in various environmental matrices has been reported. However, information on the internal
Murali K Matta et al.
JAMA, 323(3), 256-267 (2020-01-22)
A prior pilot study demonstrated the systemic absorption of 4 sunscreen active ingredients; additional studies are needed to determine the systemic absorption of additional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recommended by the US Food
Quantification of prominent organic UV filters and their metabolites in human urine and plasma samples
Klotz et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1125, 121706-121706 (2019)

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