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Supelco

Nodularin solution

10 μg/mL in methanol, analytical standard

Synonim(y):

Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-Dβ-aspartyl-L-arginyl), Nodularin-R solution

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About This Item

Wzór empiryczny (zapis Hilla):
C41H60N8O10
Numer CAS:
118399-22-7
Masa cząsteczkowa:
824.96
Numer WE:
200-659-6
Numer MDL:
MFCD16659855
Kod UNSPSC:
85151701
Identyfikator substancji w PubChem:
329754016
NACRES:
NA.24

klasa czystości

analytical standard

Poziom jakości

100

okres trwałości

limited shelf life, expiry date on the label

stężenie

10 μg/mL in methanol

metody

HPLC: suitable
gas chromatography (GC): suitable

Zastosowanie

cleaning products
cosmetics
food and beverages
personal care

format

single component solution

temp. przechowywania

−20°C

ciąg SMILES

CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(C)\C=C\[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)\C(=C\C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]2C)C(O)=O)C(O)=O

InChI

1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8-/t24-,25-,26-,28-,29-,30+,32-,34+/m0/s1

Klucz InChI

IXBQSRWSVIBXNC-HSKGSTCASA-N

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Opis ogólny

Nodularins belong to the class of hepatotoxic cyclic pentapeptides and have their structures resembling to that of microcystins. They are produced by Nodularia spumigena cyanobacterium.

Zastosowanie

Nodularin may be used as an analytical reference standard for the determination of the analyte in:
  • Surface and drinking waters by on-line solid phase extraction (SPE) and ultra high pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).
  • Sediments and pore waters by accelerated solvent extraction (ASE) and HPLC-MS/MS.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H225,H301 + H311 + H331,H370

Klasyfikacja zagrożeń

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organy docelowe

Eyes

Kod klasy składowania

3 - Flammable liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

51.8 °F

Temperatura zapłonu (°C)

11 °C

Środki ochrony indywidualnej

Eyeshields, Faceshields, Gloves

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Certyfikaty analizy (CoA)

Lot/Batch Number
BCCL8293
BCCK2671
BCCH5977
BCCG9874
BCCG1730

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

J Al-Tebrineh et al.
Toxicon : official journal of the International Society on Toxinology, 57(4), 546-554 (2011-01-05)
Toxin-producing cyanobacteria are a worldwide threat to both human and animal health. The hepatotoxins microcystin and nodularin are the most commonly occurring toxins produced by bloom-forming cyanobacteria. They are cyclic peptides that are synthesized nonribosomally by a multienzyme complexes encoded
Rebecca A Halvorson et al.
Analytical chemistry, 83(24), 9273-9280 (2011-11-01)
Raman spectra of microcystin-LR (MC-LR), MC-RR, MC-LA, MC-LF, MC-LY, MC-LW, MC-YR, and nodularin collected by drop-coating deposition Raman (DCDR) spectroscopy are sufficiently unique for variant identification. Amino acid spectra of L-phenylalanine, L-leucine, L-alanine, D-alanine, L-glutamic acid, L-arginine, L-tryptophan, L-tyrosine, and
Andrea Gambaro et al.
Rapid communications in mass spectrometry : RCM, 26(12), 1497-1506 (2012-05-18)
Cyanobacteria are a small group of photosynthetic planktonic bacteria, producing a large group of strong hepatotoxins called microcystins (MCs). Many studies have been conducted to evaluate the presence of MCs and nodularin (NOD) in water or in marine organisms, but
S A Wood et al.
Journal of environmental monitoring : JEM, 13(6), 1617-1624 (2011-04-15)
The cyanobacterial toxins, nodularin and microcystin, are highly efficient inhibitors of cellular protein phosphatases. Toxicity primarily evolves following ingestion of cyanobacterial material or toxins and results in liver and renal pathology. Ingestion is the main route of exposure in the
Lars Herfindal et al.
Molecular pharmaceutics, 8(2), 360-367 (2011-01-11)
We have isolated a novel cyanobacterial cyclic peptide (nostocyclopeptide M1; Ncp-M1) that blocks the hepatotoxic action of microcystin (MC) and nodularin (Nod). We show here that Ncp-M1 is nontoxic to primary hepatocytes in long-term culture. Ncp-M1 does not affect any
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