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Dokumenty

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Supelco

Chlorpromazine hydrochloride

VETRANAL®, analytical standard

Synonim(y):

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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About This Item

Wzór empiryczny (zapis Hilla):
C17H19ClN2S · HCl
Numer CAS:
69-09-0
Masa cząsteczkowa:
355.33
Beilstein:
3779989
Numer WE:
200-701-3
Numer MDL:
MFCD00012654
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329753883
NACRES:
NA.24

klasa czystości

analytical standard

Poziom jakości

100

linia produktu

VETRANAL®

okres trwałości

limited shelf life, expiry date on the label

metody

HPLC: suitable
gas chromatography (GC): suitable

Zastosowanie

forensics and toxicology
pharmaceutical (small molecule)

format

neat

ciąg SMILES

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

Klucz InChI

FBSMERQALIEGJT-UHFFFAOYSA-N

informacje o genach

human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356)

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Opis ogólny

Chlorpromazine hydrochloride (CPZ) is an antipsychotic drug which belongs to phenothiazine neuroleptic group. It is used in treating mental or personality disorders.

Zastosowanie

CPZ may have been used as standard for the determination of antipsychotic drug at a glassy carbon electrode using chemometric methods, such as classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Działania biochem./fizjol.

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Informacje prawne

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbones
GHS06

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H301,H330

Zwroty wskazujące środki ostrożności

P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233

Klasyfikacja zagrożeń

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certyfikaty analizy (CoA)

Lot/Batch Number
BCCF9060
BCBV3536
BCBS3655V
SZBF216XV
SZBF118XV

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Voltammetric determination of chlorpromazine hydrochloride and promethazine hydrochloride with the use of multivariate calibration.
Ni, Yongnian, Li Wang, and Serge Kokot.
Analytica Chimica Acta, 439.1, 159-168 (2001)
Jessica M D'Amico et al.
Journal of neurophysiology, 109(6), 1473-1484 (2012-12-12)
In animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-HT2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents
Laura Caldinelli et al.
Biochimica et biophysica acta, 1832(3), 400-410 (2012-12-12)
Considering the key role of d-serine in N-methyl-d-aspartate receptor-mediated neurotransmission, it is highly relevant to define the role that enzymes play in d-serine synthesis and degradation. In particular, the details of regulation of the d-serine catabolic human enzyme d-amino acid
Cristiane Flora Villarreal et al.
Pharmacology, biochemistry, and behavior, 103(3), 678-683 (2012-11-28)
In recent years, evidence that sensitization of primary afferent nociceptors is an important event associated with chronic pain has been accumulating. The present study aimed to evaluate the participation of the prostaglandin and sympathetic components in the long-lasting sensitization of
Jessica J W Broeders et al.
Toxicology in vitro : an international journal published in association with BIBRA, 27(3), 1057-1064 (2013-02-05)
The extrapolation of in vitro to in vivo toxicity data is a challenge. Differences in sensitivity between cell systems may be due to intrinsic properties of the cell but also because of differences in exposure. In this study, the cytotoxicity
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