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691400

Zebularine

Name: Zebularine
Brand: MM
Price: 1260 PLN
Availability: InStock

≥95% (HPLC), cytidine deaminase inhibitor, solid

Synonim(y):

Zebularine, 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside

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Rozmiar/SKU	Dostępność	Cena netto
10 mg	Przewidywana wysyłka DZISIAJzKuehne + Nagel Sp. z o.o.	1260,00 zł
25 mg	Przewidywana wysyłka DZISIAJzKuehne + Nagel Sp. z o.o.	2060,00 zł 1751,00 zł
	Przewidywany termin wysyłki25 września 2026zKuehne + Nagel Sp. z o.o.	81 140,00 zł
1 g	Przewidywany termin wysyłki10 listopada 2026zKuehne + Nagel Sp. z o.o.	103 310,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₉H₁₂N₂O₅

Numer CAS:

3690-10-6

Masa cząsteczkowa:

228.20

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD04973699

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze

1260,00 zł

Przewidywana wysyłka DZISIAJSzczegóły

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Właściwości

Nazwa produktu

Zebularine, A cell-permeable chemically stable cytidine analog that displays antitumor properties.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 5 mg/mL, methanol: 5 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

N2(C=CC=NC2=O)C1OC(C(C1O)O)CO

InChI

1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2

InChI key

RPQZTTQVRYEKCR-UHFFFAOYSA-N

Opis

General description

A cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Cytidine deaminase

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

From Catalog:

Desc. Field- added "cell-permeable"

Slight warming may be required to achieve complete solubilization.

Other Notes

Cheng, J.C., et al. 2004. Cancer Cell6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst.95, 399.
Zhou, L., et al. 2002. J. Mol. Biol.321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem.57, 536.
Frick, L., et al. 1989. Biochemistry28, 9423.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Ta pozycja	189406	Z4775	124018
Sigma-Aldrich 691400 Zebularine	Sigma-Aldrich 189406 Inhibitor kinazy Aurora/Cdk	Sigma-Aldrich Z4775 Zebularine	Sigma-Aldrich 124018 Inhibitor Akt VIII, izoenzymoselektywny, Akti-1/2
description A cell-permeable chemically stable cytidine analog that displays antitumor properties.	description The Aurora Kinase/Cdk Inhibitor, also referenced under CAS 443797-96-4, controls the biological activity of Aurora Kinase/Cdk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description ≥98% (HPLC), solid	description Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a cell-permeable, reversible inhibitor of Akt1/Akt2 (IC₅₀= 58 nM, 210 nM, & 2.12 µM for Akt1, Akt2, and Akt3, respectively).
assay ≥95% (HPLC)	assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)
form solid	form solid	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition OK to freeze	storage condition protect from light, OK to freeze	storage condition -	storage condition OK to freeze, protect from light

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Klasa składowania

11 - Combustible Solids

Co się dzieje?

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)