681640

Wee1 Inhibitor

≥97% (HPLC), solid

• Synonim(y): Wee1 Inhibitor, 4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V
• Wzór empiryczny (zapis Hilla): C₂₀H₁₁ClN₂O₃
• Numer CAS: 622855-37-2
• Masa cząsteczkowa: 362.77
• MDL number: MFCD28138102
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Nazwa produktu: Wee1 Inhibitor, The Wee1 Inhibitor, also referenced under CAS 622855-37-2, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: solid
• potency: 11 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: light orange
• solubility: DMSO: 10 mg/mL, ethanol: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: Clc1c(cccc1)c2c3c(c4c([nH]c5c4cc(cc5)O)c2)[c]([nH][c]3=O)=O
• InChI: 1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)
• InChI key: DPEXRCOBPACFOO-UHFFFAOYSA-N

Opis

General description

A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC₅₀ = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC₅₀ = 440 nM).

Biochem/physiol Actions

Cell permeable: no

Product competes with ATP.

Reversible: no

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable