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557440

Ru360

Name: Ru360
Brand: MM
Price: 1560 PLN
Availability: InStock

≥97%, solid, Ca2+ uptake blocker in mitrochondria, Calbiochem^®

Synonim(y):

Ru360, (μ)[(HCO₂)(NH₃)4Ru]₂OCl₃

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Gabaryty przesyłki	SKU	Dostępność	Cena netto
500 μg		Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.	1560,00 zł
1 set		Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.	3460,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂H₂₆Cl₃N₈O₅Ru₂

Masa cząsteczkowa:

550.78

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97%

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

1560,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

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Nazwa produktu

Ru360, Ru360, is a cell-permeable oxygen-bridged dinuclear ruthenium amine complex. Binds to mitochondria with high affinity (K_d = 340 pM) and blocks Ca²⁺ uptake into mitochondria in vitro (IC₅₀ = 184 pM).

Quality Level

100

assay

≥97%

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

green

solubility

deoxygenated water: 0.5 mg/mL

shipped in

ambient

storage temp.

−20°C

Powiązane kategorie

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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Ta pozycja	124014	124013	420130
Sigma-Aldrich 557440 Ru360	Sigma-Aldrich 124014 Akt Inhibitor VII, TAT-Akt-in	Sigma-Aldrich 124013 Akt Inhibitor VI, Akt-in	Millipore 420130 JNK Inhibitor III, Cell-Permeable
form solid	form solid	form lyophilized solid	form lyophilized solid
assay ≥97%	assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility deoxygenated water: 0.5 mg/mL	solubility water: 1 mg/mL	solubility water: 1 mg/mL	solubility DMSO: 100 mg/mL, acetic acid: 100 mg/mL

General description

A cell-permeable oxygen bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (K_d = 0.34 nM) and specifically blocks Ca²⁺ uptake into mitochondria in vitro (IC₅₀ = 184 pM) and in situ in intact myocytes (for complete block after incubation with ~10 µM of Ru360 for 30 min. Does not affect other cellular Ca²⁺ transport processes involved in cardiac muscle contraction even at micromolar levels.

A cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (K_d = 340 pM). Specifically blocks Ca²⁺ uptake into mitochondria in vitro (IC₅₀ = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca²⁺ transport processes involved in cardiac muscle contraction, even at micromolar levels.

Note: 1 set = 10 x 100 µg.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Ca2+ uptake into mitochondria in vitro

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 184 pM blocking Ca2+ uptake into mitochondria in vitro; and in situ in intact myocytes; Kd = 340 pM for binding mitochondria

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Sanchez, J.A., et al. 2001. J. Physiol. 536, 387.
Bassani, R.A., et al. 1998. Cell Calcium23, 433.
Matlib, M.A., et al. 1998. J. Biol. Chem.273, 10223.
Zhou, Z., et al. 1998. J. Physiol.507 (pt 2), 379.
Emerson, J., et al. 1993. J. Am. Chem. Soc.115, 11799.
Ying, W.-L., et al. 1991. Biochemistry30, 4949.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Klasa składowania

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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SKU	NUMER GTIN
557440-1SET	07790788051501
557440-500UG	04055977268089

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