The stability of this inhibitor in cell culture media has not been evaluated in-house and is expected to vary from one cell culture model system to another. The required frequency of refreshing culture medium containing this inhibitor should be determined empirically for the specific model system. Published literature may be used as a guide.
551476
Q-VD-OPh, Non-O-methylated
≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem®
Synonim(y):
InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
1 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1310,00 zł |
5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 4240,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C26H25F2N3O6
Masa cząsteczkowa:
513.49
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
1310,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases
Quality Segment
assay
≥90% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-1
caspase-1
Product does not compete with ATP.
Reversible: no
Target IC50: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
Packaging
Packaged under inert gas
Physical form
Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.
Q-Val-Asp-CH₂-OPh
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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Ta pozycja | |||
|---|---|---|---|
| description InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases | description InSolution, ≥95% | description InSolution, ≥90%, analog inhibitor of human brain memapsin 2 | description InSolution, ≥98% |
| form liquid | form liquid | form liquid | form liquid |
| assay ≥90% (HPLC) | assay ≥95% (HPLC) | assay ≥90% (HPLC) | assay ≥98% (HPLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −70°C | storage temp. −20°C | storage temp. 2-8°C |
| storage condition desiccated (hygroscopic), protect from light, OK to freeze | storage condition OK to freeze, desiccated (hygroscopic), protect from light, avoid repeated freeze/thaw cycles | storage condition desiccated, protect from light, OK to freeze | storage condition protect from light, desiccated (hygroscopic), OK to freeze |
Klasa składowania
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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