Kluczowe dokumenty

Wyświetl całą dokumentację

Przejdź do

490070

Nitric Oxide Synthase, Neuronal Inhibitor I

Name: Nitric Oxide Synthase, Neuronal Inhibitor I
Brand: MM

The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonim(y):

Nitric Oxide Synthase, Neuronal Inhibitor I, (4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA

Zaloguj się, aby wyświetlić ceny organizacyjne i kontraktowe.

Wybierz wielkość

Zmień widok

Do Państwa/SKU	Dostępność	Cena netto

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₈H₂₁N₇O₂ · 3C₂HF₃O₂ · 2H₂O

Numer CAS:

357965-99-2

Masa cząsteczkowa:

625.40

UNSPSC Code:

12352303

NACRES:

NA.77

MDL number:

MFCD05865227

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

Informacje o cenach i dostępności nie są obecnie dostępne.

Pomoc techniczna

Potrzebujesz pomocy? Nasz zespół doświadczonych naukowców chętnie Ci pomoże.

Pozwól nam pomóc

Właściwości

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white to off-white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.[N+](=O)(N\C(=N\CCC[C@H](N)CNCCN)\N)[O-]

InChI

1S/C8H21N7O2.3C2HF3O2/c9-3-5-12-6-7(10)2-1-4-13-8(11)14-15(16)17;3*3-2(4,5)1(6)7/h7,12H,1-6,9-10H2,(H3,11,13,14);3*(H,6,7)/t7-;;;/m0.../s1

InChI key

NYWNMNBIORWOSQ-QTPLPEIMSA-N

Opis

General description

A cell-permeable, potent and highly selective inhibitor of neuronal nitric oxide synthase (nNOS); (K_i = 120 nM). Displays >2500-fold and 320-fold selectivity over eNOS and iNOS, respectively.

A cell-permeable, potent, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS) (K_i = 120 nM). Displays >2,500-fold and 192-fold selectivity over eNOS and iNOS, respectively.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
nNOS

Product does not compete with ATP.

Reversible: no

Target K_i: 120 nM against nNOS

Packaging

Packaged under inert gas

Physical form

Supplied as a dihydrate.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hah, J.M., et al. 2001. J. Med. Chem.44, 2667.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Ta strona może zawierać tekst przetłumaczony maszynowo.

Porównaj podobne pozycje

Wyświetl pełne porównanie

Pokaż różnice

1 of 1

Ta pozycja	100050	324759	361549
Sigma-Aldrich 490070 Nitric Oxide Synthase, Neuronal Inhibitor I	Sigma-Aldrich 100050 1400W	Sigma-Aldrich 324759 Elastase Inhibitor IV	Sigma-Aldrich 361549 Inhibitor GSK-3β VIII
description The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.	description A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; K_d = 7 nM).	description The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.	description The GSK-3β Inhibitor VIII, also referenced under CAS 487021-52-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
form solid	form solid	form solid	form solid
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition OK to freeze, protect from light, desiccated (hygroscopic)	storage condition OK to freeze, desiccated (hygroscopic)	storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c