480066
Necrostatin-1, Inactive Control
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 that is devoid of anti-necroptotic properties and serves as a suitable inactive control.
Synonim(y):
Necrostatin-1, Inactive Control, 5-(Indol-3-ylmethyl)-2-thiohydantoin, Nec-1i
Wybierz wielkość
| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
5 mg | Przewidywany termin wysyłki16 września 2026zKuehne + Nagel Sp. z o.o. | 650,00 zł |
Informacje o tej pozycji
650,00 zł
Przewidywany termin wysyłki16 września 2026Szczegóły
Quality Segment
assay
≥95% (HPLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
light yellow
solubility
DMSO: 10 mg/mL, methanol: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C12H11N3OS/c16-11-10(14-12(17)15-11)5-7-6-13-9-4-2-1-3-8(7)9/h1-4,6,10,13H,5H2,(H2,14,15,16,17)
InChI key
MPLRRPKKFHUEEL-UHFFFAOYSA-N
General description
Note: This inactive inhibitor of necrosis should not be used in high concentration.
Biochem/physiol Actions
Inactive control for Nec-1 (Cat. No. 480065)
Packaging
Preparation Note
Other Notes
Degterev, A., et al. 2005. Nat. Chem. Biol.1, 112.
Legal Information
Disclaimer
1 of 1
Ta pozycja | |||
|---|---|---|---|
| description A cell-permeable N-demethylated thiohydantoin analog of Nec-1 that is devoid of anti-necroptotic properties and serves as a suitable inactive control. | description Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α). | description The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. | description ≥98% (HPLC), solid |
| form crystalline solid | form crystalline solid | form solid | form solid |
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (sum of two isomers, HPLC) | assay ≥98% (HPLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, methanol: 5 mg/mL | solubility DMSO: 10 mg/mL, methanol: 5 mg/mL | solubility ethanol: 10 mg/mL, DMSO: 10 mg/mL | solubility DMSO: >10 mg/mL |
Klasa składowania
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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