434625

Leukotriene B₄

≥97% (HPLC), oil, proinflammatory agent, Calbiochem^®

• Synonim(y): Leukotriene B₄, LTB₄, 5(S),12(R)-Dihydroxy-6- cis-8- trans-10- trans-14- cis-eicosatetraenoic Acid
• Wzór empiryczny (zapis Hilla): C₂₀H₃₂O₄
• Numer CAS: 71160-24-2
• Masa cząsteczkowa: 336.47
• UNSPSC Code: 12352211
• NACRES: NA.77
• MDL number: MFCD00135630
• Assay: ≥97% (HPLC)
• Form: oil
• Storage condition: OK to freeze

Właściwości

• Nazwa produktu: Leukotriene B₄, Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium.
• description: Merck USA index - 14, 5455
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: oil
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: clear
• solubility: ethanol: soluble
• shipped in: wet ice
• storage temp.: −70°C
• SMILES string: OC(CCCC(=O)O)\C=C\C=C\C=C\C(O)C\C=C\CCCCC
• InChI: 1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6+,14-10+,15-11+
• InChI key: VNYSSYRCGWBHLG-XUOUMLBJSA-N

Opis

General description

Potent inflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema.

Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema and asthma.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Polymorphonuclear leukocytes

Product does not compete with ATP.

Reversible: no

Physical form

In Ethanol.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kendall, A.P., et al. 1995. Anesthesia 50, 590.
Dokter, W.H., et al. 1994. Leukemia 8, 1181.
Jedlitschky, G., et al. 1991. J. Biol. Chem.266, 24763.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Flammable (J)

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS07
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H225,H319
• Ostrzeżenia: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Klasa składowania: 3 - Flammable liquids
• Co się dzieje?: WGK 2