219555

Cathepsin K Substrate II, Fluorogenic

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

• Synonim(y): Cathepsin K Substrate II, Fluorogenic
• Wzór empiryczny (zapis Hilla): C₄₀H₅₀N₁₄O₁₂
• Masa cząsteczkowa: 918.91
• NACRES: NA.77
• UNSPSC Code: 51111800
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated, protect from light
• color: bright yellow
• solubility: DMSO: 5 mg/mL
• fluorescence: λ_ex 320 nm; λ_em 420 nm
• shipped in: wet ice
• storage temp.: −20°C

Opis

General description

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/K_m = 0.426 µM^-1 S^-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK^-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates. Emission Max: 420 NM, Excitation Max: 320 nM.

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Abz-His-Pro-Gly~Gly-Pro-Gln-EDDnp

Lecaille, F., et al. 2003. Biochem. J.375, 307.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable