208923

CaMKII Inhibitor XII

• Synonim(y): CaMKII Inhibitor XII, Ca ²⁺/Calmodulin-Dependent Protein Kinase II Inhibitor XII
• Wzór empiryczny (zapis Hilla): C₂₉H₃₀ClN₅O₂S
• Masa cząsteczkowa: 548.10
• NACRES: NA.28
• UNSPSC Code: 12352200
• Assay: ≥99% (HPLC)
• Form: powder
• Storage condition: OK to freeze, protect from light

Właściwości

• assay: ≥99% (HPLC)
• Quality Segment: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 100 mg/mL
• shipped in: wet ice
• storage temp.: 2-8°C

Opis

General description

A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC₅₀ = 0.063 µM) with excellent selectivity over several kinases (IC₅₀ = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708 ).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Asano, S., et al. 2010. Bioorg. Med. Chem. Lett.20, 6696.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable