926027

NanoFabTX^™-DOTAP Lipid Mix

for synthesis of cationic (DOTAP) liposomes

• Synonim(y): Drug delivery, LNP, Microfluidics, NanoFab reagent kit, Nanoformulation, Nanoparticle
• NACRES: NA.23
• UNSPSC Code: 12162002
• Storage temp.: −20°C

Właściwości

• Quality Segment: 100
• storage temp.: −20°C

Opis

General description

NanoFabTx^™-DOTAP Lipid Mix includes reagents and optimized protocols with step-by-step instructions for synthesizing cationic liposomes for drug delivery research applications. The modification of liposomes with the cationic lipid, DOTAP, have numerous advantages such as their large-DNA incorporation, high transfection efficiency, and low toxicity. Liposome-based formulations are widely used for drug delivery applications and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins, and peptides.

Comprehensive protocols for liposome synthesis are included:

• A lipid film hydration and extrusion protocol.
• A microfluidics protocol using commercial platforms or syringe pumps.

The microfluidics protocol included with this product uses NanoFabTx^™ device kits (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Application

NanoFabTx^™-DOTAP Lipid Mix is a ready-to-use nanoformulation blend for the synthesis of cationic DOTAP-functionalized liposomes. This kit enables users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx^™ kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx^™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.

Features and Benefits

• A ready-to-use nanoformulation blend for the synthesis of cationic liposomes
• Step-by-step protocols (extrusion or microfluidic) developed and tested by our formulation scientists
• Flexible synthesis tools to create uniform and reproducible liposomes
• Optimized to make liposomes around 100 nm with low polydispersity
• DOTAP surface-functionalized allows for targeting ligand conjugation to enable targeted drug delivery

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3