480894

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

96%

• Wzór empiryczny (zapis Hilla): C₅H₁₁NO₂
• Numer CAS: 6723-30-4
• Masa cząsteczkowa: 117.15
• NACRES: NA.22
• PubChem Substance ID: 24871725
• UNSPSC Code: 12352100
• MDL number: MFCD01321374
• Assay: 96%

Właściwości

• Quality Segment: 200
• assay: 96%
• bp: 81 °C/20 mmHg (lit.)
• mp: 34-37 °C (lit.)
• functional group: ether
• SMILES string: NOC1CCCCO1
• InChI: 1S/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2
• InChI key: NLXXVSKHVGDQAT-UHFFFAOYSA-N

Opis

General description

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine (OTX) is an O-substituted hydroxylamine. The coupling of OTX with alkaline gel electrophoresis has been reported to improve the process of detecting single strand breaks (SSBs) in DNA.

Application

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine may be used in the synthesis of 2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)acetamides.
It may be used in the synthesis of the following potential histone deacetylase (HDAC) inhibitors:

• 2-[1-(naphthalene-2-sulfonyl)-heterocyclyl]-pyrimidine-5-carboxylic acid (tetrahydropyran-2-yloxy)-amides
• (E)-3-(2-benzyl-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide
• 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxy-acrylamide

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H315,H319,H335
• Ostrzeżenia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): 179.6 °F - closed cup
• Temperatura zapłonu (°C): 82 °C - closed cup
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves