ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonimy:
AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
Gatunek:
Human ASAP2 (8853), Mouse Asap2 (211914), Rat Asap2 (362719), domestic cat ASAP2 (101095974), domestic guinea pig Asap2 (100726170), Horse ASAP2 (100072516), cow ASAP2 (618009), dog ASAP2 (475659), sheep ASAP2 (101102555), chicken ASAP2 (768599)
Identyfikator UniProtKB:
Identyfikator genu:
- Human(8853) Summary: This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
- Mouse(211914) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- Rat(362719) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- domestic cat(101095974) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- domestic guinea pig(100726170) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- Horse(100072516) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- cow(618009) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- dog(475659) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- sheep(101102555) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- chicken(768599) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- naked mole-rat(101721882) ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
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Zastosowanie
Anti-Asap2 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
esiRNA
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