Cross-Coupling Reaction Guide

Accelerate Your Discovery

With the Cross-Coupling Guide

We are excited to introduce our new Cross-Coupling Guide to support practicing chemists like you, to set up and troubleshoot some of the most commonly used cross-coupling reactions throughout academia and industry.

The Cross-Coupling Quick Guide will provide an excellent starting point and solid foothold to demystify palladium cross-coupling chemistry.

About the Author

Dr. Nick Bruno was born and raised in California, MD. He received his B.A. in 2010 from St. Mary’s College of Maryland, working under Dr. Andrew Koch.

In 2015 he received his Ph.D. from MIT in the lab of Dr. Steve Buchwald where he worked on the development of palladium precatalysts for cross-coupling.

"Catalyst Generation"

"Setting Up a Cross-Coupling Reaction"

"General Troubleshooting"

"Buchwald-Hartwig Amination:
Primary & Secondary Amines"

"Buchwald-Hartwig Amidation: Amides"

"Suzuki–Miyaura Coupling"

"Negishi Coupling"

"Sonogashira Coupling"