1492200

Palonosetron hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): (3aS)-2-[(3S)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride, (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-Benz[de]isoquinolin-1-one hydrochloride (1:1), RS 25259-197
• Empirical Formula (Hill Notation): C₁₉H₂₄N₂O · HCl
• CAS Number: 135729-62-3
• Molecular Weight: 332.87
• NACRES: NA.24
• PubChem Substance ID: 329750657
• UNSPSC Code: 41116107
• MDL number: MFCD00939524

Properties

• grade: pharmaceutical primary standard
• API family: palonosetron
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: O=C1N([C@H]2C3CCN(CC3)C2)C[C@]4([H])C5=C1C=CC=C5CCC4.[H]Cl
• InChI: 1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1
• InChI key: OLDRWYVIKMSFFB-SSPJITILSA-N
• Gene Information: human ... HTR3A(3359)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Palonosetron hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Palonosetron is a potent and selective 5-HT3 receptor antagonist (Aloxi) used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

Palonosetron is a potent and selective 5-HT3 receptor antagonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable