MYO7A (myosin VIIA) or HM7A consists of 5 isoleucine-glutamine (IQ) motifs. It is present in retinal epithelial cells. It also interacts with other USH1 (Usher syndrome type 1B) gene products like harmonin and sans. This gene is located on human chromosome 11q13.
Immunogen
MYO7A (NP_000251, 2118 a.a. ~ 2213 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
MYO7A (myosin VIIA) or HM7A is involved in anchoring and holding membrane-bound elements to the actin core of the stereocilium. It acts as a transporter. This protein may participate in the tethering of melanosomes at the root of actin bundles. HM7A is responsible for Usher syndrome type 1B. In mice and humans, alteration in Myo7a causes hereditary deafness.
Physical form
Solution in phosphate buffered saline, pH 7.4
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Structure and Regulation of the Movement of Human Myosin VIIA
Sakai T, et al.
The Journal of Biological Chemistry, 17587-17598 (2015)
The genomic structure of the gene defective in Usher syndrome type Ib (MYO7A)
Kelley PM, et al.
Genomics, 40(1), 73-79 (1997)
Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations
Kros CJ, et al.
Nature Neuroscience (2002)
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