T9825
Tau-383 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
Synonym(s):
MAPTL, MTBT1, TAU
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| Size/SKU | Availability | Price |
|---|---|---|
50 μg | Please contact Customer Service for Availability | PLN 2,710.00 |
About This Item
Form:
lyophilized powder
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
40 kDa
biological source
human
Quality Segment
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
40 kDa
technique(s)
western blot: suitable
suitability
suitable for Western blot
UniProt accession no.
application(s)
cell analysis
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MAPT(4137)
General description
Research area: Neuroscience
Tau-383 belongs to the neuronal microtubule-associated protein family and is found in the axons of the CNS (central nervous system). It is encoded by the MAPT (microtubule associated protein tau) gene on chromosome 17q21 and exists in the form of 6 isoforms produced by the alternative splicing of m-RNA transcripts of MAPT (microtubule associated protein tau).
Tau-383 belongs to the neuronal microtubule-associated protein family and is found in the axons of the CNS (central nervous system). It is encoded by the MAPT (microtubule associated protein tau) gene on chromosome 17q21 and exists in the form of 6 isoforms produced by the alternative splicing of m-RNA transcripts of MAPT (microtubule associated protein tau).
Application
The product can be utilized for systemic identification of Phosphorylation sites in microtubule-associated protein tau by using checkpoint kinases Chk1 and Chk2 in vitro.[1]
Biochem/physiol Actions
Microtubule-associated protein tau is mainly involved in promoting the assembly and stability of microtubules in axons. The N terminal domain of tau protein is responsible for many important functions including regulation of microtubule dynamics, and spacing between microtubules and cell compartments. While the proline rich domain of the tau protein plays a key role in neuronal signaling, functioning, and maintenance of the cytoskeleton. The interaction between tau and the microtubules plays a crucial role in regulating cell signaling, synaptic plasticity, and genomic stability. Thus, an impaired interaction between Tau and microtubules leads to the development of several neurodegenerative diseases.
Isoform of Tau, variant 0N4R, having 4 microtubule binding repeats (R) and no amino terminal inserts (N)
Preparation Note
Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥90% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay ≥85% (SDS-PAGE) | assay >90% (SDS-PAGE) |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant - |
| technique(s) western blot: suitable | technique(s) - | technique(s) - | technique(s) - |
| biological source human | biological source human | biological source human | biological source human |
| mol wt 40 kDa | mol wt 36.8 kDa | mol wt 42.6 kDa | mol wt - |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form powder |
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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