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T7165

Tyrphostin 23

≥98%

Synonym(s):

(3,4-Dihydroxybenzylidene)malononitrile, RG-50810

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
PLN 538.00
25 mg
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PLN 2,180.00

About This Item

Empirical Formula (Hill Notation):
C10H6N2O2
CAS Number:
118409-57-7
Molecular Weight:
186.17
NACRES:
NA.77
PubChem Substance ID:
24278041
UNSPSC Code:
12352200
MDL number:
MFCD00133899
Assay:
≥98%
Form:
powder

PLN 538.00

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biological source

synthetic (organic)

Quality Segment

100

assay

≥98%

form

powder

potency

35 μM IC50

solubility

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1O)\C=C(\C#N)C#N

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

InChI key

VTJXFTPMFYAJJU-UHFFFAOYSA-N

Gene Information

human ... CDK2(1017)

Application

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells[1]. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils[2].

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain[3],[4].

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
T7040T3434M9440
Tyrphostin 23 ≥98%

Sigma-Aldrich

T7165

Tyrphostin 23

Tyrphostin 1 ≥98%

Sigma-Aldrich

T7040

Tyrphostin 1

Tyrphostin AG 490 solid

Sigma-Aldrich

T3434

Tyrphostin AG 490

Methyl-3,4-dephostatin >98% (HPLC), powder

Sigma-Aldrich

M9440

Methyl-3,4-dephostatin

assay

≥98%

assay

≥98%

assay

≥98% (HPLC)

assay

>98% (HPLC)

form

powder

form

solid

form

solid

form

powder

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

solubility

chloroform: soluble 50 mg/mL, clear, light yellow, DMSO: soluble

solubility

DMSO: soluble 10 mg/ml, clear, yellow, ethanol: 5 mg/mL, H2O: insoluble

solubility

DMSO: soluble 18 mg/mL, H2O: insoluble

Gene Information

human ... CDK2(1017)

Gene Information

human ... EGFR(1956)

Gene Information

human ... EGFR(1956), ERBB2(2064), IL2(3558), JAK2(3717)

Gene Information

human ... PTPN1(5770)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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