Yes, Tyrphostin 1 is an alternative designation for Tyrphostin A1.
T7040
Tyrphostin 1
≥98%
Synonym(s):
(4-Methoxybenzylidene)malononitrile
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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Please contact Customer Service for Availability | PLN 786.00 |
About This Item
Linear Formula:
CH3OC6H4CH=C(CN)2
CAS Number:
Molecular Weight:
184.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98%
Form:
solid
Quality Segment
assay
≥98%
form
solid
potency
>1250 μM IC50 (negative control)
mp
113-116 °C (lit.)
solubility
chloroform: soluble 50 mg/mL, clear, light yellow, DMSO: soluble
storage temp.
2-8°C
SMILES string
COc1ccc(cc1)\C=C(/C#N)C#N
InChI
1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
InChI key
UOHFCPXBKJPCAD-UHFFFAOYSA-N
Gene Information
human ... EGFR(1956)
Application
Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells[1].
Biochem/physiol Actions
EGFR tyrosine kinase inhibitor.
Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation[2],[3]. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells[4],[5].
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% | assay ≥98% | assay ≥98% | assay ≥98% (HPLC) |
| form solid | form solid | form powder | form solid |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility chloroform: soluble 50 mg/mL, clear, light yellow, DMSO: soluble | solubility 0.1 M HCl: soluble <0.4 mg/mL, DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless, ethanol: soluble 10 mg/mL, methylene chloride: soluble 10 mg/mL, 0.1 M NaOH: insoluble, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble | solubility DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow | solubility DMSO: soluble ~10 mg/mL |
| potency >1250 μM IC50 (negative control) | potency - | potency 35 μM IC50 | potency - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Does the product T7040, Tyrphostin 1 refer to the same compound as Tyrphostin A1?
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