The T2011 product does not contain ovoinhibitor, while the T9253 product contains ovoinhibitor, which results in chymotrypsin inhibition. For information regarding the availability of this product, please contact local customer service.
T2011
Trypsin inhibitor
powder
Synonym(s):
Ovomucoid
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250 MG
PLN 600.00
500 MG
PLN 1,070.00
1 G
PLN 1,600.00
5 G
PLN 7,220.00
PLN 600.00
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About This Item
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Product Name
Trypsin inhibitor from chicken egg white, Type III-O (free of ovoinhibitor)
biological source
chicken egg white
type
Type III-O (free of ovoinhibitor)
form
powder
mol wt
27 kDa
solubility
water: soluble 10 g/L
storage temp.
2-8°C
Quality Level
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1 of 4
This Item | |||
|---|---|---|---|
| biological source chicken egg white | biological source chicken egg white | biological source - | biological source Glycine max (soybean) |
| Quality Level 300 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| form powder | form powder | form lyophilized solid | form lyophilized powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility water: soluble 10 g/L | solubility water: soluble 10 g/L | solubility 67 mM potassium phosphate buffer, pH 7.6: 5 mg/mL | solubility - |
| mol wt 14 kDa | mol wt 14 kDa | mol wt - | mol wt - |
General description
Ovomucoid or trypsin inhibitor is an abundant protein in most avian egg whites. The hen′s egg protein is composed of about 186 amino acid residues, and is highly glycosylated. Three tandem domains are each homologous with pancreatic trypsin inhibitor. It is highly immunogenic, and probably accounts for most cases of egg allergy.
Application
Trypsin inhibitor from chicken egg white has been used:
- to terminate proteolysis reaction
- in OVO-1 solution to triturate the cell suspension for the dissociation of retina
- in phosphate buffered saline for dissociation of cortices
Biochem/physiol Actions
Ovomucoid possesses trypsin inhibitor activity. It has several conformational and linear epitopes that can be bound by immunoglobulin E (IgE). It is highly stable against heat and proteolysis.
Other Notes
One trypsin unit will produce a ΔA253 of 0.001 per min with BAEE as substrate at pH 7.6 at 25 °C; reaction volume 3.2 mL, 1 cm light path.
View more information on Trypsin Inhibitor.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Allergy, asthma & immunology research, 5(1), 42-47 (2013-01-02)
It is known that ovomucoid, an egg allergen, is heat resistant and remains soluble after heating. However, a recent study showed that the antigenic activity of ovomucoid could be reduced by heating when egg white (EW) was mixed with wheat
Ovomucoid specific immunoglobulin E as a predictor of tolerance to cooked egg
Bartnikas LM, et al.
Allergy & rhinology (Providence, R.I.), 6(3), ar-2015 (2015)
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Protocols
Do pomiaru aktywności inhibitora trypsyny stosuje się spektrofotometryczny test oznaczania szybkości przy 253 nm. Jedna jednostka enzymu spowoduje zmianę absorbancji przy użyciu BAEE jako substratu.
This technical article described the Enzymatic Assay of Trypsin Inhibitor.
Related Content
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