SML3870
Fuzapladib
≥98% (HPLC)
Synonym(s):
IS 741, IS-741, N-(2-((ethylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-3-yl]cyclohexanecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C15H20F3N3O3S
CAS Number:
Molecular Weight:
379.40
MDL number:
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Cell penetrant and potent phospholipase A2 (PLA2) inhibitor
Fuzapladib (IS-741) is a cell penetrant and potent phospholipase A2 (PLA2) inhibitor. Fuzapladib decelerate the progression of pancreatic fibrosis through monocyte infiltration in dogs.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Nanocrystal solid dispersion of fuzapladib free acid with improved oral bioavailability
Biopharmaceutics & Drug Disposition, 43(3), 89-97 (2022)
Effect of IS-741 on ethionine-induced acute pancreatitis in rats: relation to pancreatic acinar cell regeneration
Journal of Gastroenterology, 38(3), 260-267 (2003)
Effects of IS-741, a synthetic anti-inflammatory agent, on bleomycin-induced lung injury in mice
Lung, 187(5), 331-339 (2009)
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