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SML3839

Danirixin

≥98% (HPLC)

Synonym(s):

3-{4-Chloro-2-hydroxy-3-[(3S)-piperidine-3-sulfonyl]phenyl}-1-(3-fluoro-2-methylphenyl)urea, GSK 1325756, GSK 1325756B, GSK-1325756, GSK-1325756B, GSK1325756, GSK1325756B, N-[4-Chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N′-(3-fluoro-2-methylphenyl)urea

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
669,00 PLN
25 mg
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2.690,00 PLN

About This Item

Empirical Formula (Hill Notation):
C19H21ClFN3O4S
CAS Number:
Molecular Weight:
441.90
UNSPSC Code:
51111800
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder

669,00 PLN


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

O=C(NC1=CC=C(C(S([C@H]2CCCNC2)(=O)=O)=C1O)Cl)NC3=C(C(F)=CC=C3)C

InChI key

NGYNBSHYFOFVLS-LBPRGKRZSA-N

Biochem/physiol Actions

Danirixin (GSK1325756) is an orally active, selective CXC chemokine receptor 2 (CXCR2) antagonist with 78-fold lower affinity toward CXCR1 (CXCR2/CXCR1 IC50 = 12.5/977 nM by competitive binding against 0.225 nM [125I] CXCL8). Danirixin blocks agonist-induced neutrophil CD11b expression in vitro (IC50 = 420/890 nM against induction by 10 nM human CXCL1/rat CXCL2 using rat/human whole blood) and prevents lung neutrophils influx in rats in vivo following aerosol lipopolysaccharide or ozone challenge (ED50 = 1.4 and 16 mg/kg, respectively).
Orally active, selective CXC chemokine receptor 2 (CXCR2) antagonist.

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This Item
SML2655
description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

storage temp.

-10 to -25°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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